Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385175 | 0.81 | MAPK13 (0.47) | SIGMAR1KCNN4HTTCHRNB2CHRNB4 | |
| SCHEMBL20385091 | 0.67 | SIGMAR1 (0.38) | SIGMAR1HTTALDH1A1L3MBTL1 | |
| SCHEMBL20385118 | 0.67 | ALDH1A1 (0.48) | SIGMAR1ALDH1A1 | |
| SCHEMBL27742167 | 0.66 | CASP3 (0.48) | SIGMAR1BCAT2ALDH1A1CASP3SENP8 | |
| SCHEMBL20385123 | 0.64 | GRIN2D (0.50) | SIGMAR1HTTALDH1A1MAPT | |
| SCHEMBL23288540 | 0.62 | SIGMAR1 (0.33) | SIGMAR1HTTALDH1A1MAPT | |
| SCHEMBL8243220 | 0.61 | NPC1 (0.36) | SIGMAR1ALDH1A1MAPT | |
| SCHEMBL7738018 | 0.61 | SIGMAR1 (0.48) | SIGMAR1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL19380616 | 0.61 | HPGD (0.68) | HTTALDH1A1CASP3MAPT | |
| SCHEMBL7398164 | 0.60 | BCAT2 (0.48) | HTTCHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867215-B1 | TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | SANIONA AS (DK) | 2018-07-18 | — | — | EP | disclosed |