Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 3/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399751 | 1.00 | OPRK1 (0.34) | OPRK1OPRD1KDM4EMITFHSP90AA1 | |
| SCHEMBL21528222 | 0.80 | JAK2 (0.42) | KDM4E | |
| SCHEMBL28196771 | 0.77 | POLB (0.33) | — | |
| SCHEMBL12142325 | 0.76 | METAP1 (0.33) | MITFHSP90AA1METAP1CCR6 | |
| SCHEMBL3169586 | 0.74 | FAAH (0.42) | — | |
| SCHEMBL9052963 | 0.72 | TACR3 (0.43) | KDM4E | |
| SCHEMBL15352654 | 0.72 | TACR3 (0.43) | KDM4E | |
| SCHEMBL21081462 | 0.72 | LMNA (0.35) | — | |
| SCHEMBL22634130 | 0.72 | LMNA (0.35) | — | |
| SCHEMBL504706 | 0.72 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3570838-B1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY INC (US) | 2024-06-05 | — | — | EP | disclosed |
| US-20240043387-A1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY INC (US) | 2024-02-08 | — | — | US | disclosed |
| US-11319290-B2 | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210101868-A1 | Substituted 3-Dialkylaminomethyl-Piperidin-4-yl-Benzamides and Methods of Making and Using Same | MEBIAS DISCOVERY, INC. | 2021-04-08 | — | — | US | disclosed |
| US-10836728-B2 | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| US-20190337901-A1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY, INC. | 2019-11-07 | — | — | US | disclosed |
| WO-2018136546-A1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY LLC (US) | 2018-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210101868-A1 | Substituted 3-Dialkylaminomethyl-Piperidin-4-yl-Benzamides and Methods of Making and Using Same | ALKBH5, ALKBH2, ALKBH3 | OPRK1 13/4885OPRD1 388/4885KDM4E 103/4885 |
| US-20240043387-A1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | ALKBH5, ALKBH2, ALKBH3 | OPRK1 13/4885OPRD1 388/4885KDM4E 103/4885 |
| US-10836728-B2 | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same | ALKBH5, ALKBH2, ALKBH3 | OPRK1 13/4885OPRD1 388/4885KDM4E 103/4885 |
| US-20190337901-A1 | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME | ALKBH5, ALKBH2, ALKBH3 | OPRK1 13/4885OPRD1 388/4885KDM4E 103/4885 |
| US-11319290-B2 | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same | ALKBH5, ALKBH2, ALKBH3 | OPRK1 13/4885OPRD1 388/4885KDM4E 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.