Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23612477 | 0.84 | TDP1 (0.41) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20424503 | 0.83 | LMNA (0.31) | TDP1ALDH1A1TRPA1LMNACHRM1 | |
| SCHEMBL20424969 | 0.83 | LMNA (0.41) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL23589330 | 0.83 | HTR2B (0.33) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL20424530 | 0.81 | HTR2B (0.35) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20424779 | 0.80 | ACHE (0.43) | ALDH1A1MEN1KMT2AMAPTPKM | |
| SCHEMBL23589331 | 0.80 | GRM7 (0.32) | ALDH1A1ALOX5GAANPSR1 | |
| SCHEMBL23589316 | 0.79 | ADORA2A (0.35) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL20424790 | 0.79 | PKM (0.43) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL20425142 | 0.79 | ALOX5 (0.33) | TDP1ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573972-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2026-01-14 | — | — | EP | disclosed |
| EP-3573974-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2024-09-18 | — | — | EP | disclosed |
| US-11974997-B2 | RORgamma modulators and uses thereof | GENFIT (FR) | 2024-05-07 | — | — | US | disclosed |
| EP-3573961-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2023-10-25 | — | — | EP | disclosed |
| EP-3573961-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2023-10-25 | — | — | EP | disclosed |
| EP-3573960-B1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2023-08-16 | — | — | EP | disclosed |
| EP-3573960-B1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2023-08-16 | — | — | EP | disclosed |
| US-20220133716-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2022-05-05 | — | — | US | disclosed |
| US-20220133716-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2022-05-05 | — | — | US | disclosed |
| US-11160801-B2 | RORgamma modulators and uses thereof | GENFIT (FR) | 2021-11-02 | — | — | US | disclosed |
| US-11160801-B2 | RORgamma modulators and uses thereof | GENFIT (FR) | 2021-11-02 | — | — | US | disclosed |
| US-11077115-B2 | Rorgamma modulators and uses thereof | GENFIT (FR) | 2021-08-03 | — | — | US | disclosed |
| US-11052092-B2 | N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases | GENFIT (FR) | 2021-07-06 | — | — | US | disclosed |
| US-11052092-B2 | N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases | GENFIT (FR) | 2021-07-06 | — | — | US | disclosed |
| US-10987351-B2 | RORgamma modulators and uses thereof | GENFIT (FR) | 2021-04-27 | — | — | US | disclosed |
| US-10987351-B2 | RORgamma modulators and uses thereof | GENFIT (FR) | 2021-04-27 | — | — | US | disclosed |
| WO-2018138356-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018138359-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018138354-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018138362-A1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11052092-B2 | N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases | RORA, RORC, RORB | TDP1 4432/4885ALDH1A1 118/4885MEN1 4303/4885 |
| US-20220133716-A1 | RORGAMMA MODULATORS AND USES THEREOF | RORB, RORC, RORA | TDP1 4839/4885ALDH1A1 1352/4885MEN1 3748/4885 |
| US-11974997-B2 | RORgamma modulators and uses thereof | RORB, RORC, RORA | TDP1 4839/4885ALDH1A1 1352/4885MEN1 3748/4885 |
| US-10987351-B2 | RORgamma modulators and uses thereof | RORB, RORC, RORA | TDP1 4864/4885ALDH1A1 761/4885MEN1 3498/4885 |
| US-11160801-B2 | RORgamma modulators and uses thereof | RORB, RORC, RORA | TDP1 4839/4885ALDH1A1 1352/4885MEN1 3748/4885 |
| US-11077115-B2 | Rorgamma modulators and uses thereof | RORB, RORC, RORA | TDP1 4864/4885ALDH1A1 761/4885MEN1 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.