Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.37 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980901 | 0.83 | ESR1 (0.58) | SLC6A2SLC6A4SLC6A3SMN1; SMN2TNNC1 | |
| SCHEMBL20428022 | 0.83 | SCN5A (0.46) | — | |
| SCHEMBL27980731 | 0.81 | ESR1 (0.55) | SLC6A2SLC6A4SLC6A3SMN1; SMN2KDM4E | |
| SCHEMBL20428004 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL20427997 | 0.78 | CNR2 (0.34) | KCNH2 | |
| SCHEMBL20428003 | 0.77 | RECQL (0.42) | SMN1; SMN2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL22856972 | 0.76 | LMNA (0.47) | SLC6A2SLC6A4SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL11147321 | 0.75 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL25825947 | 0.75 | LMNA (0.46) | SLC6A2SLC6A4SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL811576 | 0.74 | KCNH2 (0.73) | KCNH2SLC6A2SLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | KCNH2 1711/4885SLC6A2 4710/4885SLC6A4 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.