Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13755347 | 0.85 | HDAC4 (0.45) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL21937614 | 0.77 | HDAC4 (0.40) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL872816 | 0.72 | CYP3A4 (0.51) | HDAC4SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL7570645 | 0.71 | HDAC4 (0.43) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL12203839 | 0.71 | HDAC4 (0.49) | HDAC4SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL7564524 | 0.70 | PSEN1 (0.43) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL8766211 | 0.69 | HSD11B1 (0.53) | HDAC4SLC6A4SLC6A3PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL2142 | 0.68 | SLC6A3 (0.36) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL15042455 | 0.68 | HDAC4 (0.40) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL15042437 | 0.68 | ESR1 (0.41) | HDAC4SLC6A4SLC6A3SLC6A2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | HDAC4 875/4885SLC6A4 4653/4885SLC6A3 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.