Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | AOC2 | O75106 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223202 | 0.89 | CHRM2 (0.43) | CHRM2CHRM1CHRM3NCF1AOC2 | |
| SCHEMBL14147384 | 0.87 | CHRM2 (0.51) | CHRM2CHRM1CHRM3NCF1PLG | |
| SCHEMBL15945549 | 0.82 | THRA (0.42) | CHRM2CHRM1CHRM3AOC2CXCR3 | |
| SCHEMBL3316595 | 0.82 | EPHX2 (0.41) | AOC2CXCR3CNR2DPP4DRD2 | |
| SCHEMBL10215111 | 0.82 | AOC2 (0.43) | AOC2CXCR3CNR2DPP4DRD2 | |
| SCHEMBL3316244 | 0.81 | CXCR3 (0.38) | AOC2CXCR3CNR2DPP4ITGB3 | |
| SCHEMBL18997472 | 0.81 | GNAI3 (0.43) | AOC2CXCR3CNR2DPP4DRD2 | |
| SCHEMBL18702106 | 0.80 | CNR2 (0.35) | CHRM2CHRM1CHRM3NCF1AOC2 | |
| SCHEMBL12308621 | 0.80 | CHRM2 (0.43) | CHRM2CHRM1CHRM3NCF1ITGB3 | |
| SCHEMBL3119356 | 0.79 | ALDH1A1 (0.39) | CHRM2CHRM1CHRM3AOC2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2020-10-08 | — | — | US | disclosed |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-23 | — | — | US | disclosed |
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-16 | — | — | US | disclosed |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, WNT3A, WNT1 | CHRM2 4881/4885CHRM1 4884/4885CHRM3 4860/4885 |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | CHRM2 4857/4885CHRM1 4788/4885CHRM3 4879/4885 |
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MCL1, MKI67 | CHRM2 4737/4885CHRM1 4660/4885CHRM3 4561/4885 |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, GLI1, WNT1 | CHRM2 4845/4885CHRM1 4862/4885CHRM3 4799/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | CHRM2 4857/4885CHRM1 4788/4885CHRM3 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.