Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.54 |
| ▸ | F13A1 | P00488 | 1/20 | 0.54 |
| ▸ | TGM1 | P22735 | 1/20 | 0.54 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782552 | 0.95 | TGM2 (1.00) | TGM2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL14341775 | 0.91 | TGM2 (0.86) | TGM2SMN1; SMN2MTNR1AMTNR1BLMNA | |
| SCHEMBL8467427 | 0.90 | TGM2 (0.90) | TGM2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL8151744 | 0.88 | MTNR1B (0.74) | TGM2SMN1; SMN2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL9017578 | 0.85 | TGM2 (1.00) | TGM2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL20456243 | 0.83 | TGM2 (0.73) | TGM2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL20554088 | 0.83 | TGM2 (0.62) | TGM2MTNR1AMTNR1BMAP2K7EGFR | |
| SCHEMBL20469621 | 0.83 | TGM2 (0.68) | TGM2SMN1; SMN2RAB9ALMNAMAP2K7 | |
| SCHEMBL20456556 | 0.83 | TGM2 (0.68) | TGM2SMN1; SMN2LMNAMAP2K7F13A1 | |
| SCHEMBL18559537 | 0.82 | TGM2 (0.71) | TGM2SMN1; SMN2NPC1RAB9AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062696-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-27 | — | — | US | disclosed |
| US-20200062696-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-27 | — | — | US | disclosed |
| CN-110461322-A | For inhibiting the composition and method of plasma membrane protein 4 | UNIV CALIFORNIA | 2019-11-15 | — | — | CN | disclosed |
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | FRONTIER MEDICINES CORPORATION | 2019-09-26 | — | — | US | disclosed |
| WO-2018144870-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018144870-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062696-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 | RTN4, RTN3, RCN1 | TGM2 2492/4885SMN1; SMN2 2138/4885NPC1 2442/4885 |
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | ATG7, BECN1, SQSTM1 | TGM2 2225/4885SMN1; SMN2 3721/4885NPC1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.