Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20464260 | 0.89 | MAPK1 (0.38) | ALDH1A1RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL19699546 | 0.85 | SMN1; SMN2 (0.47) | ALDH1A1RAB9ANPC1TP53CCNE1 | |
| SCHEMBL26764538 | 0.77 | NOTUM (0.46) | ALDH1A1RAB9ANPC1TP53CCNE1 | |
| SCHEMBL13057030 | 0.74 | FFAR2 (0.58) | ALDH1A1RAB9ANPC1TP53CYP2C19 | |
| SCHEMBL15000512 | 0.73 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1TP53CCNE1 | |
| SCHEMBL19699499 | 0.73 | SMN1; SMN2 (0.45) | ALDH1A1RAB9ANPC1TP53CCNE1 | |
| SCHEMBL12690425 | 0.73 | HCAR3 (0.40) | RAB9ANPC1KDM4EL3MBTL1MAPT | |
| SCHEMBL9891790 | 0.72 | RAB9A (0.68) | ALDH1A1RAB9ANPC1TP53LMNA | |
| SCHEMBL10068186 | 0.72 | XIAP (0.49) | ALDH1A1RAB9ATP53CDK2CDK5 | |
| SCHEMBL19699500 | 0.71 | ALDH1A1 (0.40) | ALDH1A1RAB9ANPC1TP53CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222882-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222882-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | RORC, RORB, RORA | ALDH1A1 374/4885RAB9A 2135/4885NPC1 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.