Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053914 | 0.85 | KDM4E (0.46) | CNR2TP53CNR1NPSR1POLB | |
| SCHEMBL3757847 | 0.82 | GPR35 (0.48) | CNR2CNR1POLBMCL1ALDH1A1 | |
| SCHEMBL4395300 | 0.80 | CCR2 (0.52) | CNR2CNR1POLBMCL1ALDH1A1 | |
| SCHEMBL2053661 | 0.79 | CNR2 (0.46) | CNR2TP53POLBCCNCCDK8 | |
| SCHEMBL29750342 | 0.78 | ALDH1A1 (0.64) | CNR2POLBMCL1ALDH1A1CYP1A2 | |
| SCHEMBL7894118 | 0.78 | ALDH1A1 (0.64) | CNR2POLBMCL1ALDH1A1CYP1A2 | |
| SCHEMBL23418448 | 0.78 | NPC1 (0.42) | CNR2CNR1MAPTPOLBMCL1 | |
| SCHEMBL3758947 | 0.77 | MCL1 (0.56) | CNR2MAPTPOLBMCL1ALDH1A1 | |
| SCHEMBL3005616 | 0.77 | CCR2 (0.62) | CNR2TP53CNR1ALDH1A1CYP1A2 | |
| SCHEMBL7686579 | 0.76 | KDM4E (0.44) | CNR2MCL1ALDH1A1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519520-A1 | [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLOPYRIDINYL)-METHANONE DERIVATIVES AS TRYPTASE INHIBITORS | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| WO-2011078984-A1 | [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011078984-A1 | [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | CMA1, TPSB2, TPH1 | CNR2 166/4885TP53 4700/4885CNR1 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.