Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053736 | 0.85 | PPARG (0.48) | ACSS2KDM4EMAPTRAB9APPARG | |
| SCHEMBL2018223 | 0.73 | ADORA2A (0.40) | ACSS2TLR8MEN1KMT2AMAPT | |
| SCHEMBL2016331 | 0.73 | HTT (0.52) | ACSS2TLR8MEN1KMT2AKDM4E | |
| SCHEMBL2018097 | 0.70 | HTT (0.59) | ACSS2MEN1THRBKMT2AKDM4E | |
| SCHEMBL2018088 | 0.69 | TNF (0.53) | ACSS2TLR8MEN1KMT2AKDM4E | |
| SCHEMBL7257387 | 0.67 | MAPT (0.60) | MEN1THRBKMT2AKDM4EMAPT | |
| SCHEMBL2015344 | 0.67 | HTT (0.47) | MEN1KMT2AMAPTRAB9AHTT | |
| SCHEMBL2017836 | 0.65 | HTT (0.46) | ACSS2MEN1THRBKMT2AHTT | |
| SCHEMBL12635694 | 0.65 | HTT (0.52) | ACSS2MEN1THRBKMT2AKDM4E | |
| SCHEMBL20209144 | 0.64 | ACSS2 (0.57) | ACSS2MEN1THRBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |