SCHEMBL20528840

SCHEMBL20528840

O=C(CBr)Nc1cc(NC(=O)CBr)cc(C(=O)ON2C(=O)CCC2=O)c1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
HPGD P15428 1/20 0.39
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
ALOX12 P18054 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.34
PKM P14618 1/20 0.34
MAPT P10636 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HSD17B10 Q99714 2/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
BLM P54132 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22845003 0.86 ALDH1A1 (0.40) ALDH1A1HPGDMEN1KMT2AL3MBTL1
SCHEMBL7769437 0.86 ALDH1A1 (0.54) ALDH1A1HPGDMEN1KMT2AALOX12
SCHEMBL19911199 0.78 NSD2 (0.40) ALDH1A1HPGDMEN1KMT2AMAPT
SCHEMBL13404895 0.77 MGLL (0.37) ALDH1A1HPGDMEN1KMT2AL3MBTL1
SCHEMBL22833046 0.76 KDM4E (0.54) ALDH1A1HPGDMEN1KMT2AL3MBTL1
SCHEMBL10076741 0.74 L3MBTL1 (0.45) ALDH1A1HPGDMEN1KMT2AL3MBTL1
SCHEMBL12092089 0.74 L3MBTL1 (0.54) ALDH1A1MEN1KMT2AL3MBTL1MAPT
SCHEMBL16053638 0.73 ACP1 (0.44) MEN1KMT2AMAPTCYP3A4
SCHEMBL17747110 0.72 CA12 (0.46) ALDH1A1HPGDMEN1KMT2AL3MBTL1
SCHEMBL2590087 0.72 NOTUM (0.36) ALDH1A1HPGDKMT2AALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210393745-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE NOVO NORDISK A/S (DK) 2021-12-23 US claimed
EP-3863680-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE Novo Nordisk A/S (DK) 2021-08-18 EP claimed
CN-112839681-A Oligomer-extended insulin-Fc conjugates and medical uses thereof 诺和诺德股份有限公司 2021-05-25 CN claimed
EP-4700044-A1 PROTEIN ANALOGUE AND USE THEREOF Shanghai Duomirui Biotechnology., Ltd. (CN) 2026-02-25 EP disclosed
WO-2024199481-A1 PROTEIN ANALOGUE AND USE THEREOF 上海多米瑞生物技术有限公司 2024-10-03 WO disclosed
US-11471537-B2 Oligomer extended insulin-Fc conjugates NOVO NORDISK A/S (DK) 2022-10-18 US disclosed
US-20210393745-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE NOVO NORDISK A/S (DK) 2021-12-23 US disclosed
US-20210393745-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE NOVO NORDISK A/S (DK) 2021-12-23 US disclosed
EP-3863680-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE Novo Nordisk A/S (DK) 2021-08-18 EP disclosed
CN-112839681-A Oligomer-extended insulin-Fc conjugates and medical uses thereof 诺和诺德股份有限公司 2021-05-25 CN disclosed
US-20200261595-A1 Oligomer Extended Insulin-FC Conjugates NOVO NORDISK A/S (DK) 2020-08-20 US disclosed
US-20200261595-A1 Oligomer Extended Insulin-FC Conjugates NOVO NORDISK A/S (DK) 2020-08-20 US disclosed
EP-3606560-A2 OLIGOMER EXTENDED INSULIN-FC CONJUGATES Novo Nordisk A/S (DK) 2020-02-12 EP disclosed
WO-2018185131-A2 OLIGOMER EXTENDED INSULIN-FC CONJUGATES NOVO NORDISK A/S (DK) 2018-10-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200261595-A1 Oligomer Extended Insulin-FC Conjugates IAPP, IDE, INSR ALDH1A1 4710/4885HPGD 4347/4885MEN1 381/4885
US-20210393745-A1 OLIGOMER EXTENDED INSULIN-FC CONJUGATES AND THEIR MEDICAL USE IAPP, IDE, INSR ALDH1A1 4730/4885HPGD 4265/4885MEN1 375/4885
US-11471537-B2 Oligomer extended insulin-Fc conjugates IAPP, IDE, INSR ALDH1A1 4710/4885HPGD 4347/4885MEN1 381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.