SCHEMBL10076741

SCHEMBL10076741

O=C(CI)Nc1cccc(C(=O)ON2C(=O)CCC2=O)c1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.45
ALDH1A1 P00352 6/20 0.45
KMT2A Q03164 4/20 0.43
TSHR P16473 2/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 2/20 0.42
HSD17B10 Q99714 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
LMNA P02545 3/20 0.41
RAB9A P51151 2/20 0.41
MAPT P10636 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12092089 0.88 L3MBTL1 (0.54) L3MBTL1ALDH1A1KMT2ATSHRSMN1; SMN2
SCHEMBL109045 0.84 ALDH1A1 (0.54) ALDH1A1KMT2ATSHRHPGDMEN1
SCHEMBL15080489 0.81 L3MBTL1 (0.43) L3MBTL1ALDH1A1KMT2ATSHRHPGD
SCHEMBL16450930 0.81 ALDH1A1 (0.46) L3MBTL1ALDH1A1KMT2ASMN1; SMN2MEN1
SCHEMBL10105974 0.81 L3MBTL1 (0.42) L3MBTL1ALDH1A1KMT2ATSHRHPGD
SCHEMBL14860981 0.79 MAPK1 (0.48) L3MBTL1ALDH1A1KMT2ATSHRHPGD
SCHEMBL13248996 0.78 MAPT (0.46) ALDH1A1KMT2ASMN1; SMN2MEN1LMNA
SCHEMBL9315250 0.78 MGLL (0.56) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL317765 0.76 MAPK1 (0.43) ALDH1A1KMT2AHPGDCYP1A2CYP3A4
SCHEMBL4393639 0.76 TSHR (0.45) ALDH1A1KMT2ATSHRMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242922-A1 GENE EDITING TOOLS LIFE TECHNOLOGIES CORP (US) 2023-08-03 US disclosed
US-20230242922-A1 GENE EDITING TOOLS LIFE TECHNOLOGIES CORP (US) 2023-08-03 US disclosed
US-11701433-B2 Complexes for delivery of antigenic peptides THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2023-07-18 US disclosed
US-11701433-B2 Complexes for delivery of antigenic peptides THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2023-07-18 US disclosed
US-20200129640-A1 COMPLEXES FOR DELIVERY OF ANTIGENIC PEPTIDES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-04-30 US disclosed
EP-2598507-B1 ANTICANCER DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2017-05-31 EP disclosed
US-9056914-B2 Anticancer derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2015-06-16 US disclosed
US-9056914-B2 Anticancer derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2015-06-16 US disclosed
US-8952147-B2 Conjugates, preparation thereof, and therapeutic use thereof SANOFI (FR) 2015-02-10 US disclosed
US-8952147-B2 Conjugates, preparation thereof, and therapeutic use thereof SANOFI (FR) 2015-02-10 US disclosed
US-20120046240-A9 Method of Producing Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2012-02-23 US disclosed
US-20120046240-A9 Method of Producing Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2012-02-23 US disclosed
WO-2012014147-A1 ANTICANCER DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-02-02 WO disclosed
US-20110054152-A1 Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2011-03-03 US disclosed
US-20110054152-A1 Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2011-03-03 US disclosed
WO-2011001052-A1 NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-01-06 WO disclosed
US-20100317609-A1 Method of Producing Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2010-12-16 US disclosed
US-20100317609-A1 Method of Producing Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2010-12-16 US disclosed
US-7815893-B2 Hydroxyalkyl starch derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2010-10-19 US disclosed
US-7815893-B2 Hydroxyalkyl starch derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2010-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11701433-B2 Complexes for delivery of antigenic peptides IFNG, ALB, IFNAR1 L3MBTL1 3246/4885ALDH1A1 4069/4885KMT2A 3440/4885
US-20110054152-A1 Hydroxyalkyl Starch Derivatives GRHPR, DCXR, HRH2 L3MBTL1 4571/4885ALDH1A1 1415/4885KMT2A 4511/4885
US-20120046240-A9 Method of Producing Hydroxyalkyl Starch Derivatives HACL2, HAAO, LIPA L3MBTL1 4722/4885ALDH1A1 304/4885KMT2A 4044/4885
US-20200129640-A1 COMPLEXES FOR DELIVERY OF ANTIGENIC PEPTIDES IFNG, ALB, IFNAR1 L3MBTL1 3246/4885ALDH1A1 4069/4885KMT2A 3440/4885
US-20100317609-A1 Method of Producing Hydroxyalkyl Starch Derivatives HACL2, HAAO, LIPA L3MBTL1 4722/4885ALDH1A1 304/4885KMT2A 4044/4885
US-20230242922-A1 GENE EDITING TOOLS DCLRE1B, DNASE1L3, FEN1 L3MBTL1 89/4885ALDH1A1 3455/4885KMT2A 2375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.