SCHEMBL2053315

SCHEMBL2053315

Fc1ccc(-c2ccc[c]c2C(F)(F)F)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 2/20 0.35
GPBAR1 Q8TDU6 1/20 0.33
ABCC8 Q09428 1/20 0.33
KCNJ11 Q14654 1/20 0.33
GPR3 P46089 1/20 0.33
AKR1C3 P42330 1/20 0.31
AKR1C2 P52895 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
MAPK14 Q16539 1/20 0.31
HSD11B1 P28845 1/20 0.31
ALDH1A1 P00352 1/20 0.31
PIK3R1 P27986 1/20 0.30
PIK3CA P42336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2050765 0.87 PTPN1 (0.36) PDK2GPBAR1PDE3BPDE3A
SCHEMBL15637439 0.83 GPR3 (0.33) GPR3
SCHEMBL2431241 0.82 HTR1A (0.33) PDK2GPBAR1GPR3HSD11B1ALDH1A1
SCHEMBL436195 0.79 GPR3 (0.36) PDK2GPR3MAPK14ALDH1A1PIK3R1
SCHEMBL2431522 0.77 ENPP1 (0.39) PDK2MAPK14HSD11B1
SCHEMBL2430766 0.77 NT5E (0.41) PDK2PDE3BPDE3A
SCHEMBL2053486 0.76 MAPK14 (0.35) GPR3MAPK14HSD11B1ALDH1A1PIK3R1
SCHEMBL2015762 0.76 HTR1A (0.35)
SCHEMBL2051089 0.76 HSD11B1 (0.38) PDK2GPBAR1PDE3BPDE3AHSD11B1
SCHEMBL15637654 0.76 PIK3R1 (0.37) PDK2GPR3PDE3BPDE3AMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2903440-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES Bayer CropScience AG (DE) 2015-08-12 EP disclosed
WO-2014053450-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2014-04-10 WO disclosed
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed