SCHEMBL20537147

SCHEMBL20537147

O=[N+]([O-])c1ccc(Cl)c(-c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.58
KMT2A Q03164 9/20 0.58
MEN1 O00255 7/20 0.58
NPSR1 Q6W5P4 6/20 0.58
ALDH1A1 P00352 4/20 0.58
HTT P42858 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
TDP1 Q9NUW8 4/20 0.55
GAA P10253 2/20 0.55
KDM4E B2RXH2 2/20 0.55
ALOX12 P18054 1/20 0.55
NPBWR1 P48145 3/20 0.55
LMNA P02545 4/20 0.53
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 1/20 0.51
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2126513 0.81 MAPT (0.74) MAPTKMT2AMEN1NPSR1ALDH1A1
SCHEMBL9514606 0.80 KMT2A (0.68) MAPTKMT2AMEN1NPSR1ALDH1A1
SCHEMBL2127659 0.80 KMT2A (0.68) MAPTKMT2AMEN1NPSR1ALDH1A1
SCHEMBL29568028 0.79 NPBWR1 (0.73) MAPTKMT2AMEN1NPSR1ALDH1A1
SCHEMBL2689294 0.79 NPBWR1 (0.73) MAPTKMT2AMEN1NPSR1ALDH1A1
SCHEMBL20537158 0.78 MGAM (0.54) MAPTKMT2AMEN1ALDH1A1KDM4E
SCHEMBL1040038 0.77 MAPK13 (0.67) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL306063 0.77 MAPK13 (0.67) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL29360656 0.77 MAPK13 (0.67) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL27652680 0.77 HSD17B10 (0.58) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210283938-A1 A LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA NV (BE) 2021-09-16 US disclosed
CN-110546567-A Lithographic printing plate precursor AGFA NV 2019-12-06 CN disclosed
EP-3392709-A1 A LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA NV (BE) 2018-10-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210283938-A1 A LITHOGRAPHIC PRINTING PLATE PRECURSOR LOXL1, LOXL2, LOXL3 MAPT 939/4885KMT2A 2209/4885MEN1 3980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.