Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexadecylamine SCHEMBL28110136 | 0.93 | DNM1 (0.56) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL1123062 | 0.91 | LMNA (0.57) | LMNADNM1TSHRMEN1KMT2A | |
| Hexadecane SCHEMBL28823222 | 0.91 | LMNA (0.57) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL28823240 | 0.91 | LMNA (0.57) | LMNADNM1TSHRMEN1KMT2A | |
| Ethylenediamine SCHEMBL27500208 | 0.91 | LMNA (0.50) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL1780545 | 0.91 | LMNA (0.65) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL304612 | 0.91 | LMNA (0.65) | LMNADNM1TSHRMEN1KMT2A | |
| Hexane SCHEMBL6049081 | 0.91 | LMNA (0.65) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL35912 | 0.91 | LMNA (0.65) | LMNADNM1TSHRMEN1KMT2A | |
| SCHEMBL377101 | 0.91 | LMNA (0.65) | LMNADNM1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115944726-A | Chemically modified B 4 C nanoparticles and applications thereof | 无锡市南京大学锡山应用生物技术研究所 | 2023-04-11 | — | — | CN | claimed |
| CN-115944726-A | Chemically modified B 4 C nanoparticles and applications thereof | 无锡市南京大学锡山应用生物技术研究所 | 2023-04-11 | — | — | CN | disclosed |
| US-20220402944-A1 | Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2022-12-22 | — | — | US | disclosed |
| US-11420986-B2 | Functionalized mesoporous silica via an aminosilane surfactant ion exchange reaction: controlled scaffold design and nitric oxide release | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3750624-A1 | FUNCTIONALIZED MESOPOROUS SILICA VIA AN AMINOSILANE SURFACTANT ION EXCHANGE REACTION: CONTROLLED SCAFFOLD DESIGN AND NITRIC OXIDE RELEASE | The University of North Carolina at Chapel Hill (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-3371198-B1 | METHOD OF PRODUCING NO-RELEASING MESOPOROUS SILICA PARTICLES VIA AN AMINOSILANE-SURFACTANT ION EXCHANGE REACTION | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2020-09-09 | — | — | EP | disclosed |
| US-20180319822-A1 | Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402944-A1 | Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release | SRM, NOS1, NOS3 | LMNA 2435/4885DNM1 1177/4885TSHR 1203/4885 |
| US-11420986-B2 | Functionalized mesoporous silica via an aminosilane surfactant ion exchange reaction: controlled scaffold design and nitric oxide release | SRM, NOS1, NOS3 | LMNA 2435/4885DNM1 1177/4885TSHR 1203/4885 |
| US-20180319822-A1 | Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release | SRM, NOS1, NOS3 | LMNA 2414/4885DNM1 1221/4885TSHR 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.