Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23114101 | 0.84 | HPGD (0.36) | HPGDHIF1APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL30514411 | 0.81 | IDO1 (0.47) | HPGDALDH1A1LMNAMAPT | |
| SCHEMBL4535306 | 0.78 | HIF1A (0.51) | HIF1APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL23113902 | 0.78 | HPGD (0.36) | HPGDHIF1APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7186116 | 0.75 | CXCL8 (0.47) | PTGS2CLCN2CLIC1CXCL8 | |
| SCHEMBL3529974 | 0.75 | HPGD (0.67) | HPGDPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL1180411 | 0.74 | HIF1A (0.67) | HPGDHIF1APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL28753564 | 0.73 | HPGD (0.50) | HPGDHIF1APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL8094360 | 0.72 | ALOX5 (0.33) | — | |
| SCHEMBL27611366 | 0.72 | HPGD (0.49) | HPGDPLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-08-01 | — | — | US | disclosed |
| EP-3625222-B1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-07-21 | — | — | EP | disclosed |
| US-20200179383-A1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2020-06-11 | — | — | US | disclosed |
| EP-3625222-A1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018210994-A1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | HPGD 283/4885HIF1A 1062/4885PLAAT3 819/4885 |
| US-20200179383-A1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | PTGER1, PTGER4, PTGER2 | HPGD 307/4885HIF1A 999/4885PLAAT3 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.