Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30216284 | 0.98 | MEN1 (0.40) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL22346156 | 0.89 | MEN1 (0.39) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL20974036 | 0.89 | MEN1 (0.39) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL23879650 | 0.86 | HSD11B1 (0.47) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL19188365 | 0.84 | MEN1 (0.38) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL11953286 | 0.84 | MEN1 (0.35) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL30562194 | 0.84 | MEN1 (0.40) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL1536186 | 0.84 | MEN1 (0.40) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL24031854 | 0.83 | MEN1 (0.41) | MEN1MAPK1KMT2ACTSLDGAT1 | |
| SCHEMBL20243118 | 0.83 | MEN1 (0.41) | MEN1MAPK1KMT2ADGAT1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704090-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-05-27 | — | — | EP | disclosed |
| EP-3710428-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-25 | — | — | EP | disclosed |
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| US-12404248-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-09-02 | — | — | US | disclosed |
| US-20250195513-A1 | DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2025-06-19 | — | — | US | disclosed |
| US-20250145594-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2025-05-08 | — | — | US | disclosed |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2025-04-17 | — | — | US | disclosed |
| US-20250019376-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | MERCK SHARP & DOHME LLC (US) | 2025-01-16 | — | — | US | disclosed |
| US-12138265-B2 | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2024-11-12 | — | — | US | disclosed |
| EP-4201924-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2024-10-23 | — | — | EP | disclosed |
| US-11021466-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200383984-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2020-12-10 | — | — | US | disclosed |
| US-20200383984-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2020-12-10 | — | — | US | disclosed |
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200291032-A1 | PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-09-17 | — | — | US | disclosed |
| WO-2020117634-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2020-05-21 | — | — | US | disclosed |
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2020-05-21 | — | — | US | disclosed |
| US-10336762-B2 | Pyrrolo[1,2-b]pyridazine derivatives | GILEAD SCIENCES, INC. (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200383984-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | CDK9, IRAK1, CSNK1A1 | MEN1 4397/4885MAPK1 177/4885KMT2A 1264/4885 |
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HUWE1, APP, PSEN1 | MEN1 998/4885MAPK1 980/4885KMT2A 2045/4885 |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | MEN1 4714/4885MAPK1 239/4885KMT2A 4320/4885 |
| US-20250019376-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | PAM, ACMSD, MGAM2 | MEN1 270/4885MAPK1 352/4885KMT2A 1492/4885 |
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | MEN1 3601/4885MAPK1 914/4885KMT2A 2312/4885 |
| US-20200291032-A1 | PYRIMIDINE DERIVATIVES | TYMS, DPYD, TYMP | MEN1 2275/4885MAPK1 3096/4885KMT2A 2112/4885 |
| US-11021466-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | MEN1 3601/4885MAPK1 914/4885KMT2A 2312/4885 |
| US-12138265-B2 | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use | CDK9, IRAK1, CSNK1A1 | MEN1 4419/4885MAPK1 168/4885KMT2A 1222/4885 |
| US-10336762-B2 | Pyrrolo[1,2-b]pyridazine derivatives | SDHB, CYP4F2, CYP1B1 | MEN1 1506/4885MAPK1 1817/4885KMT2A 3113/4885 |
| US-20250195513-A1 | DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | IRAK4, IRAK2, IRAK3 | MEN1 3739/4885MAPK1 1825/4885KMT2A 637/4885 |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | MEN1 3601/4885MAPK1 914/4885KMT2A 2312/4885 |
| US-20250145594-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | MEN1 4684/4885MAPK1 339/4885KMT2A 4179/4885 |
| US-12404248-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | MEN1 3601/4885MAPK1 914/4885KMT2A 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.