Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20592780 | 0.82 | METAP2 (0.42) | BRD4CREBBPSSTR4SCN9ANAMPT | |
| SCHEMBL20593084 | 0.80 | NMT1 (0.36) | BRD4SCN9ANAMPT | |
| SCHEMBL22450707 | 0.78 | L3MBTL1 (0.44) | SSTR4SCN9ANAMPTGRIN1GRIN2B | |
| SCHEMBL18359230 | 0.75 | HTR7 (0.38) | SCN9AGRIN1GRIN2BCNR1 | |
| SCHEMBL20646913 | 0.70 | L3MBTL1 (0.44) | SSTR4GRIN1GRIN2BL3MBTL1KDM4C | |
| SCHEMBL18591437 | 0.69 | CFD (0.44) | — | |
| SCHEMBL15025470 | 0.67 | KDM4C (0.49) | SSTR4SCN9ANAMPTKDM4C | |
| SCHEMBL16252830 | 0.66 | SCN9A (0.51) | BRD4CREBBPSSTR4SCN9ANAMPT | |
| SCHEMBL29989752 | 0.65 | KDM4E (0.39) | BRD4CREBBPL3MBTL1KDM4C | |
| SCHEMBL22450682 | 0.65 | GABRA1 (0.51) | NAMPTDYRK1AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411431-A1 | Novel compounds and their use in therapy | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-12-29 | — | — | US | disclosed |
| US-11466011-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-10-11 | — | — | US | disclosed |
| EP-3313833-B1 | COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2021-01-06 | — | — | EP | disclosed |
| US-20200339586-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-10-29 | — | — | US | disclosed |
| US-10759804-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-20180370974-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759804-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | NMT1, NMT2, GNMT | BRD4 908/4885CREBBP 2606/4885SSTR4 4768/4885 |
| US-20220411431-A1 | Novel compounds and their use in therapy | NMT1, NMT2, FNTA | BRD4 892/4885CREBBP 3365/4885SSTR4 4647/4885 |
| US-11466011-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | NMT1, NMT2, GNMT | BRD4 908/4885CREBBP 2606/4885SSTR4 4768/4885 |
| US-20180370974-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | NMT1, NMT2, GNMT | BRD4 908/4885CREBBP 2606/4885SSTR4 4768/4885 |
| US-20200339586-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | NMT1, NMT2, GNMT | BRD4 908/4885CREBBP 2606/4885SSTR4 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.