Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633005 | 0.86 | LMNA (0.38) | MEN1KMT2A | |
| SCHEMBL20633441 | 0.85 | FYN (0.39) | MEN1KMT2A | |
| SCHEMBL20632673 | 0.84 | CA2 (0.36) | — | |
| SCHEMBL20633162 | 0.83 | AURKA (0.38) | MEN1POLBKMT2A | |
| SCHEMBL20632922 | 0.83 | KDM4E (0.36) | MEN1KMT2A | |
| SCHEMBL20633401 | 0.83 | HTR2C (0.42) | MEN1KMT2AROCK1ROCK2CDC7 | |
| SCHEMBL20632193 | 0.82 | FYN (0.37) | MEN1KMT2A | |
| SCHEMBL20632643 | 0.82 | CSF1R (0.38) | MEN1POLBKMT2ADDR2 | |
| SCHEMBL20632046 | 0.82 | CYP1A2 (0.43) | MEN1KMT2ATRPV1 | |
| SCHEMBL20632024 | 0.81 | RHOA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |