Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11806422 | 0.84 | NPC1 (0.59) | NPC1RAB9AMAPTALDH1A1GSK3B | |
| SCHEMBL7290567 | 0.83 | CA1 (0.54) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL863102 | 0.83 | ESR2 (0.59) | NPC1RAB9AMAPTALDH1A1TDP1 | |
| SCHEMBL6040897 | 0.81 | TPMT (0.46) | NPC1RAB9AMAPTGSK3BSMN1; SMN2 | |
| SCHEMBL3833913 | 0.81 | LMNA (0.50) | NPC1RAB9AMAPTALDH1A1GSK3B | |
| SCHEMBL20135229 | 0.81 | MAPT (0.62) | NPC1RAB9AMAPTALDH1A1TDP1 | |
| SCHEMBL19219873 | 0.81 | NPC1 (0.55) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL10796669 | 0.81 | HAO1 (0.46) | NPC1RAB9AMAPTALDH1A1GSK3B | |
| SCHEMBL246263 | 0.81 | HDAC3 (0.66) | NPC1RAB9AMAPTALDH1A1GSK3B | |
| SCHEMBL7290231 | 0.81 | GSK3B (0.41) | NPC1RAB9AMAPTALDH1A1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224851-A1 | METAL OXIDE CATALYZED RADIOFLUORINATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-10 | — | — | US | disclosed |
| EP-2062884-B1 | Phenylacetic acid derivatives and pharmaceutical composition thereof | FUJI YAKUHIN CO LTD (JP) | 2013-02-20 | — | — | EP | disclosed |
| US-8148421-B2 | Phenylacetic acid derivative | FUJI YAKUHIN CO., LTD. (JP) | 2012-04-03 | — | — | US | disclosed |
| US-20100048666-A1 | NOVEL PHENYLACETIC ACID DERIVATIVE | FUJI YAKUHIN CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| US-20090298898-A1 | PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090298898-A1 | PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-7569727-B2 | N-{(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-[(E)-ethoxyimino]-methyl}-2,2,2-trifluoroacetamide; exhibit valuable preventive and/or curative activity even at low rates of concentration, while being well tolerated by warm-blooded animals, fish and plants | SYNGENTA CROP PROTECTION, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569727-B2 | N-{(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-[(E)-ethoxyimino]-methyl}-2,2,2-trifluoroacetamide; exhibit valuable preventive and/or curative activity even at low rates of concentration, while being well tolerated by warm-blooded animals, fish and plants | SYNGENTA CROP PROTECTION, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| EP-2080752-A1 | Pesticidally active ketone and oxime derivatives | Syngenta Participations AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| EP-2062884-A1 | NOVEL PHENYLACETIC ACID DERIVATIVE | Fuji Yakuhin Co., Ltd. (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-5393924-A | Reacting an arylisonitrosoalkanone with hydrogen and carboxylic acid in presence of a transition metal hydrogenation catalyst | HOECHST CELANESE CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1995000114-A1 | TETRALINE® FORMATE ESTER AROMA CHEMICALS | UNION CAMP CORPORATION (US) | 1995-01-05 | — | — | WO | disclosed |
| US-5349090-A | Process for preparing arylketoamines | HOECHST CELANESE CORPORATION (US) | 1994-09-20 | — | — | US | disclosed |
| US-5338884-A | Reacting an arylisonitrosoalkanone with hydrogen then acid, ester inpresence of catalyst | HOECHST CELANESE (US) | 1994-08-16 | — | — | US | disclosed |
| US-5292719-A | Perfumes, colognes, soaps and cosmetics; musk aroma | UNION CAMP CORPORATION (US) | 1994-03-08 | — | — | US | disclosed |
| US-5220063-A | Reacting arylisonitrosoalkanone with hydrogen and acyl doner in presence of transition metal catalyst | HOECHST CELANESE CORPORATION (US) | 1993-06-15 | — | — | US | disclosed |
| US-5198585-A | Catalytic hydrogenation of arylisonitrosoalkanone | HOECHST CELANESE CORPORATION (US) | 1993-03-30 | — | — | US | disclosed |
| WO-1993001158-A1 | METHOD FOR THE PREPARATION OF ARYLKETOAMINES | HOECHST CELANESE CORPORATION (US) | 1993-01-21 | — | — | WO | disclosed |
| EP-0481705-A1 | Process for the preparation of arylalkylamines and substituted arylalkylamines | HOECHST CELANESE CORPORATION (US) | 1992-04-22 | — | — | EP | disclosed |
| US-5041669-A | Reacting alkyl aryl ketones with alkyl nitrites, extracting product, catalytically hydrogenating/reducing in nonaqueous acid mixture | HOECHST CELANESE CORPORATION (US) | 1991-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048666-A1 | NOVEL PHENYLACETIC ACID DERIVATIVE | PTGS1, PTGER1, PTGDR | NPC1 2166/4885RAB9A 2775/4885MAPT 4810/4885 |
| US-20170224851-A1 | METAL OXIDE CATALYZED RADIOFLUORINATION | TRHDE, TPO, TERT | NPC1 3602/4885RAB9A 196/4885MAPT 3400/4885 |
| US-20090298898-A1 | PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES | CHRM2, FOXO3, CHRM1 | NPC1 2582/4885RAB9A 2029/4885MAPT 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.