Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20365038 | 0.81 | CYP2D6 (0.36) | ALDH1A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL15423927 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL24106959 | 0.78 | RIPK1 (0.39) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL15426043 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| Simufilam SCHEMBL12627054 | 0.74 | MC4R (0.46) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL24106950 | 0.74 | OPRD1 (0.46) | ALDH1A1KDM4ELMNAGAAHTT | |
| SCHEMBL15423928 | 0.74 | LMNA (0.43) | ALDH1A1KDM4ELMNASMN1; SMN2HTT | |
| Simufilam SCHEMBL22361802 | 0.73 | MC4R (0.45) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| Simufilam SCHEMBL22361808 | 0.73 | MC4R (0.45) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL15423926 | 0.73 | FAAH (0.56) | ALDH1A1KDM4EMAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882428-B1 | A METHOD OF INHIBITING TAU PHOSPHORYLATION | PAIN THERAPEUTICS INC (US) | 2019-01-16 | — | — | EP | disclosed |