Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | STAT3 | P40763 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12042426 | 0.85 | LMNA (0.72) | MMP13LMNAL3MBTL1HTTALDH1A1 | |
| SCHEMBL20672116 | 0.84 | LMNA (0.54) | GAALMNAL3MBTL1HTTALDH1A1 | |
| SCHEMBL12058757 | 0.83 | LMNA (0.69) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL1569157 | 0.82 | L3MBTL1 (0.77) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL7848467 | 0.82 | EPHX2 (0.70) | LMNAL3MBTL1HTTALDH1A1MEN1 | |
| SCHEMBL11628868 | 0.81 | CA2 (0.68) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL171661 | 0.81 | SMN1; SMN2 (0.83) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL30828595 | 0.81 | MMP13 (0.88) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| Tert-Butylamine SCHEMBL27931811 | 0.81 | L3MBTL1 (0.66) | GAAMMP13LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL18674106 | 0.81 | KDM4E (0.67) | GAALMNAL3MBTL1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | GAA 553/4885MMP13 211/4885LMNA 4544/4885 |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | GAA 553/4885MMP13 211/4885LMNA 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.