Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807409 | 0.80 | HSD11B1 (0.41) | OPRM1OPRL1ALDH1A1 | |
| SCHEMBL17446960 | 0.78 | OPRM1 (0.36) | OPRM1OPRL1ALDH1A1 | |
| SCHEMBL2805815 | 0.76 | CYP2C19 (0.45) | OPRM1OPRL1P2RX7ALDH1A1 | |
| SCHEMBL3495245 | 0.74 | CYP2C19 (0.48) | OPRM1OPRL1P2RX7ALDH1A1 | |
| SCHEMBL840651 | 0.74 | CYP2C19 (0.48) | OPRM1OPRL1P2RX7ALDH1A1 | |
| SCHEMBL14744077 | 0.74 | MCL1 (0.36) | OPRM1OPRL1P2RX7ALDH1A1 | |
| SCHEMBL17445686 | 0.74 | DPP4 (0.43) | OPRM1OPRL1 | |
| SCHEMBL29124603 | 0.74 | TSHR (0.37) | OPRM1OPRL1ALDH1A1 | |
| SCHEMBL5692544 | 0.72 | ALDH1A1 (0.38) | OPRM1OPRL1P2RX7ALDH1A1 | |
| SCHEMBL3909670 | 0.72 | CYP2C19 (0.47) | OPRM1OPRL1P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | GRUENENTHAL GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | OPRL1, OPRD1, OPRM1 | OPRM1 3/4885OPRL1 1/4885P2RX7 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.