Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840651 | 1.00 | CYP2C19 (0.48) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL3909670 | 0.98 | CYP2C19 (0.47) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL2805815 | 0.98 | CYP2C19 (0.45) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL2807409 | 0.93 | HSD11B1 (0.41) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL7552932 | 0.89 | — | — | |
| SCHEMBL5692544 | 0.81 | ALDH1A1 (0.38) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL8839908 | 0.79 | ALDH1A1 (0.37) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| Potassium Ion SCHEMBL3909671 | 0.79 | ALDH1A1 (0.37) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL14744077 | 0.78 | MCL1 (0.36) | CYP2C19ALDH1A1CYP1A2USP2LMNA | |
| SCHEMBL31119581 | 0.76 | P2RX7 (0.38) | CYP2C19ALDH1A1CYP1A2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY | 2010-06-03 | — | — | US | claimed |
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY | 2010-06-03 | — | — | US | disclosed |
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY | 2010-06-03 | — | — | US | disclosed |
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY | 2010-06-03 | — | — | US | disclosed |
| WO-2007094885-A2 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY (US) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007094885-A2 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070178575-A1 | Identification Of A Nitrilase From B. Japonicum By Rational Genome Mining And Methods Of Use | SOUTHERN METHODIST UNIVERSITY | 2007-08-02 | — | — | US | disclosed |
| US-20070178575-A1 | Identification Of A Nitrilase From B. Japonicum By Rational Genome Mining And Methods Of Use | SOUTHERN METHODIST UNIVERSITY | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | BLVRB, BBOX1, GGH | CYP2C19 1410/4885ALDH1A1 634/4885CYP1A2 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.