Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24788062 | 0.84 | SPHK1 (0.48) | SIRT1SPHK1BDKRB2S1PR1KLKB1 | |
| SCHEMBL23071786 | 0.79 | SMN1; SMN2 (0.39) | LMNASPHK1S1PR1SMN1; SMN2 | |
| SCHEMBL20051422 | 0.77 | MEN1 (0.47) | LMNAKLKB1PLGF2PLAU | |
| SCHEMBL24728476 | 0.76 | C3AR1 (0.40) | SIRT1SIRT2SPHK1SIRT5SIRT3 | |
| SCHEMBL20329050 | 0.76 | CA2 (0.42) | SIRT5 | |
| SCHEMBL25932588 | 0.76 | LTA4H (0.41) | SIRT1SIRT2SIRT5KLKB1PLG | |
| SCHEMBL21781895 | 0.75 | SIRT2 (0.33) | SIRT1SIRT2SIRT5SIRT3 | |
| SCHEMBL24701258 | 0.74 | C3AR1 (0.42) | SIRT1SIRT2SIRT5KLKB1PLG | |
| SCHEMBL24539700 | 0.74 | C3AR1 (0.42) | SIRT1SIRT2SIRT5KLKB1PLG | |
| SCHEMBL21782008 | 0.73 | CHRNB2 (0.44) | SIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019030284-A1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-02-14 | — | — | WO | disclosed |