SCHEMBL20744323

SCHEMBL20744323

Cc1nnc(Cl)cc1-c1ncccn1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.32
TDP1 Q9NUW8 2/20 0.32
PDE2A O00408 1/20 0.32
PDE10A Q9Y233 1/20 0.32
GALR2 O43603 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
MPI P34949 1/20 0.32
HTT P42858 1/20 0.32
CCR6 P51684 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
PLK4 O00444 1/20 0.31
AURKA O14965 1/20 0.31
CHEK2 O96017 1/20 0.31
CDK1 P06493 1/20 0.31
CDK2 P24941 1/20 0.31
FLT4 P35916 1/20 0.31
KDR P35968 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20743957 0.76 KDM1A (0.33)
SCHEMBL20743439 0.76 RAB9A (0.37) ALDH1A1MAPTDYRK1ANPC1RAB9A
SCHEMBL20743605 0.73 KDM4E (0.38) PDE2APDE10AALDH1A1MAPTHTT
SCHEMBL25230310 0.72 CYP1A2 (0.47) TDP1ALDH1A1MAPTHPGDNPSR1
SCHEMBL21543544 0.68 HSD11B1 (0.46) TDP1ALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL29039016 0.68 PDE2A (0.39) PDE2APDE10AALDH1A1MAPTHPGD
SCHEMBL21543055 0.68 HSD11B1 (0.44) PDE2APDE10AALDH1A1MAPTHPGD
SCHEMBL30415229 0.68 PDE2A (0.39) PDE2APDE10AALDH1A1MAPTHPGD
SCHEMBL20744294 0.68 MAOB (0.34) HDAC8NPC1NFKB1CASP3RAB9A
SCHEMBL30833320 0.68 TDP1 (0.37) TDP1MAPTHTTSMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111032640-B Herbicidal compounds 先正达参股股份有限公司 2023-08-08 CN disclosed
US-11618743-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2023-04-04 US disclosed
US-20220125051-A1 PRE-HARVEST DESICCATION METHOD SYNGENTA CROP PROTECTION AG (CH) 2022-04-28 US disclosed
US-20220125051-A1 PRE-HARVEST DESICCATION METHOD SYNGENTA CROP PROTECTION AG (CH) 2022-04-28 US disclosed
EP-3923727-A1 PRE-HARVEST DESICCATION METHOD Syngenta Crop Protection AG (CH) 2021-12-22 EP disclosed
EP-3668855-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-11-10 EP disclosed
EP-3668855-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-11-10 EP disclosed
CN-113423271-A Pre-harvest drying method 先正达农作物保护股份公司 2021-09-21 CN disclosed
US-20210009561-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
US-20210009561-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
WO-2020164971-A1 PRE-HARVEST DESICCATION METHOD SYNGENTA CROP PROTECTION AG (CH) 2020-08-20 WO disclosed
WO-2020164971-A1 PRE-HARVEST DESICCATION METHOD SYNGENTA CROP PROTECTION AG (CH) 2020-08-20 WO disclosed
EP-3668855-A1 HERBICIDAL COMPOUNDS Syngenta Participations AG (CH) 2020-06-24 EP disclosed
CN-111032640-A Herbicidal compounds 先正达参股股份有限公司 2020-04-17 CN disclosed
WO-2019034757-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-02-21 WO disclosed
WO-2019034757-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210009561-A1 HERBICIDAL COMPOUNDS DDT, ACHE, GSTO1 HDAC8 1788/4885TDP1 1845/4885PDE2A 1262/4885
US-11618743-B2 Herbicidal compounds DDT, ACHE, GSTO1 HDAC8 1788/4885TDP1 1845/4885PDE2A 1262/4885
US-20220125051-A1 PRE-HARVEST DESICCATION METHOD GMDS, TREH, DAD1 HDAC8 724/4885TDP1 2102/4885PDE2A 1591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.