Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | CBS | P35520 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20744886 | 1.00 | TSHR (0.33) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL22337957 | 0.85 | GPR55 (0.35) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL22337968 | 0.83 | GPR55 (0.33) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL20745215 | 0.82 | GPR55 (0.36) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL20745216 | 0.82 | GPR55 (0.36) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL22337986 | 0.81 | MGAM (0.34) | TSHR | |
| SCHEMBL22337953 | 0.80 | GPR55 (0.31) | TSHRCTHCBSTHPOGPR55 | |
| SCHEMBL20745010 | 0.75 | PKM (0.34) | TSHRGPR55THRB | |
| SCHEMBL20745009 | 0.75 | PKM (0.34) | TSHRGPR55THRB | |
| SCHEMBL22337961 | 0.73 | RIPK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046065-A1 | MERGING C(sp3)-H ACTIVATION WITH DNA-ENCODING | THE SCRIPPS RESEARCH INSTITUTE | 2023-02-16 | — | — | US | disclosed |
| CN-111212824-B | Directed beta-C (sp) of ketones 3 ) -H iodination and arylation | 斯克利普斯研究院 | 2022-08-16 | — | — | CN | disclosed |
| US-10875822-B2 | Directed β-C(sp3)#H iodination and arylation of ketones | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-12-29 | — | — | US | disclosed |
| US-10875822-B2 | Directed β-C(sp3)#H iodination and arylation of ketones | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200255363-A1 | Directed Beta-C(sp3)–H Iodination and Arylation of Ketones | THE SCRIPPS RESEARCH INSTITUTE | 2020-08-13 | — | — | US | disclosed |
| US-20200255363-A1 | Directed Beta-C(sp3)–H Iodination and Arylation of Ketones | THE SCRIPPS RESEARCH INSTITUTE | 2020-08-13 | — | — | US | disclosed |
| CN-111212824-A | Orientation of the ketone β -C (sp)3) -H iodination and arylation | 斯克利普斯研究院 | 2020-05-29 | — | — | CN | disclosed |
| WO-2019036349-A1 | DIRECTED B-C(SP3)-H IODINATION AND ARYLATION OF KETONES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-02-21 | — | — | WO | disclosed |
| WO-2019036349-A1 | DIRECTED B-C(SP3)-H IODINATION AND ARYLATION OF KETONES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255363-A1 | Directed Beta-C(sp3)–H Iodination and Arylation of Ketones | BCAT1, AOC3, SPIN3 | TSHR 797/4885CTH 111/4885CBS 764/4885 |
| US-10875822-B2 | Directed β-C(sp3)#H iodination and arylation of ketones | BCAT1, AOC3, SPIN3 | TSHR 726/4885CTH 102/4885CBS 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.