Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PAM | P19021 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20744888 | 1.00 | HPGD (0.42) | HPGDPAMRECQLCYP3A4CYP1A2 | |
| SCHEMBL25046047 | 0.86 | NPC1 (0.51) | HPGDALDH1A1LMNA | |
| SCHEMBL20744889 | 0.84 | HPGD (0.39) | HPGDPAMRECQLCYP3A4CYP1A2 | |
| SCHEMBL20744891 | 0.84 | HPGD (0.39) | HPGDPAMRECQLCYP3A4CYP1A2 | |
| SCHEMBL28399342 | 0.80 | TRPA1 (0.38) | HPGDPAMRECQLALDH1A1MMP8 | |
| SCHEMBL20745002 | 0.80 | MMP8 (0.59) | HPGDPAMRECQLALDH1A1MMP8 | |
| SCHEMBL20745005 | 0.80 | MMP8 (0.59) | HPGDPAMRECQLALDH1A1MMP8 | |
| SCHEMBL25045929 | 0.78 | MAPT (0.44) | HPGDCYP1A2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL20744883 | 0.75 | TSHR (0.33) | SMN1; SMN2 | |
| SCHEMBL20744886 | 0.75 | TSHR (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111212824-B | Directed beta-C (sp) of ketones 3 ) -H iodination and arylation | 斯克利普斯研究院 | 2022-08-16 | — | — | CN | disclosed |
| US-10875822-B2 | Directed β-C(sp3)#H iodination and arylation of ketones | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200255363-A1 | Directed Beta-C(sp3)–H Iodination and Arylation of Ketones | THE SCRIPPS RESEARCH INSTITUTE | 2020-08-13 | — | — | US | disclosed |
| CN-111212824-A | Orientation of the ketone β -C (sp)3) -H iodination and arylation | 斯克利普斯研究院 | 2020-05-29 | — | — | CN | disclosed |
| WO-2019036349-A1 | DIRECTED B-C(SP3)-H IODINATION AND ARYLATION OF KETONES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255363-A1 | Directed Beta-C(sp3)–H Iodination and Arylation of Ketones | BCAT1, AOC3, SPIN3 | HPGD 4562/4885PAM 2134/4885RECQL 4875/4885 |
| US-10875822-B2 | Directed β-C(sp3)#H iodination and arylation of ketones | BCAT1, AOC3, SPIN3 | HPGD 4576/4885PAM 1985/4885RECQL 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.