Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32681842 | 1.00 | DPP7 (0.35) | DPP7USP30HSD11B1L3MBTL3NPC1 | |
| SCHEMBL4798583 | 0.88 | USP30 (0.38) | DPP7USP30HSD11B1DPP4 | |
| SCHEMBL25389420 | 0.86 | DPP7 (0.34) | DPP7USP30HSD11B1NPC1RAB9A | |
| SCHEMBL22719845 | 0.83 | TEAD1 (0.46) | — | |
| SCHEMBL16765475 | 0.83 | TEAD1 (0.33) | DPP7USP30 | |
| SCHEMBL30407481 | 0.79 | GPR119 (0.49) | NPC1RAB9A | |
| SCHEMBL6214888 | 0.79 | DPP7 (0.39) | DPP7HSD11B1L3MBTL3NPC1RAB9A | |
| SCHEMBL27198362 | 0.78 | RIPK1 (0.36) | DPP7L3MBTL3DPP4 | |
| SCHEMBL20744455 | 0.78 | L3MBTL3 (0.46) | L3MBTL3 | |
| SCHEMBL4887983 | 0.76 | CHRNB2 (0.36) | USP30HSD11B1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668882-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034890-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2019-02-21 | — | — | WO | disclosed |