Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20549912 | 0.95 | FUT7 (0.41) | CA2PTPN1PSEN1PSEN2APH1B | |
| SCHEMBL20550029 | 0.95 | FUT7 (0.41) | CA2PTPN1PSEN1PSEN2APH1B | |
| SCHEMBL20549883 | 0.95 | FUT7 (0.41) | CA2PTPN1PSEN1PSEN2APH1B | |
| SCHEMBL3621448 | 0.81 | CA2 (0.54) | CA2SMN1; SMN2CNR2KEAP1NFE2L2 | |
| SCHEMBL20787587 | 0.78 | MMP12 (0.43) | CA2SMN1; SMN2PTPN1GAAMAPK1 | |
| SCHEMBL20549874 | 0.76 | CA2 (0.40) | CA2SMN1; SMN2PTPN1TDP1L3MBTL1 | |
| SCHEMBL20549877 | 0.76 | CA2 (0.52) | CA2PTPN1TDP1CA12MMP12 | |
| SCHEMBL20767982 | 0.76 | CA2 (0.52) | CA2PTPN1TDP1CA12MMP12 | |
| SCHEMBL14798196 | 0.75 | GPR3 (0.47) | SMN1; SMN2PTPN1L3MBTL1 | |
| SCHEMBL27641648 | 0.75 | CA2 (0.53) | CA2SMN1; SMN2CNR2CA12PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221153-B2 | Dibenzothiophene compounds | SAINT LOUIS UNIVERSITY (US) | 2019-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221153-B2 | Dibenzothiophene compounds | DDT, TST, MPST | CA2 4455/4885SMN1; SMN2 2300/4885METAP2 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.