Sugi Predict

Sugi Predict / Compounds / SCHEMBL2076982

SCHEMBL2076982

SCHEMBL2076982

CS(=O)(=O)OCCCOCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.47
▸ TSHR P16473 2/20 0.47
▸ LMNA P02545 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ USP2 O75604 1/20 0.47
▸ MMP9 P14780 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ CA1 P00915 2/20 0.46
▸ CA2 P00918 2/20 0.46
▸ CA9 Q16790 2/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45
▸ NAAA Q02083 1/20 0.41
▸ HPGD P15428 2/20 0.41
▸ HRH4 Q9H3N8 1/20 0.41
▸ HRH3 Q9Y5N1 1/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ AR P10275 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20294565 0.98 ALDH1A1 (0.45) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL27032046 0.97 ALDH1A1 (0.48) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL2078239 0.97 ALDH1A1 (0.52) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL2077604 0.95 L3MBTL1 (0.51) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL24773083 0.93 TSHR (0.44) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL27032384 0.93 TSHR (0.44) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL24675883 0.92 L3MBTL1 (0.49) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL20133100 0.92 L3MBTL1 (0.49) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL29198550 0.90 L3MBTL1 (0.47) ALDH1A1TSHRLMNAKDM4EUSP2
SCHEMBL2076848 0.89 TSHR (0.50) ALDH1A1TSHRLMNAKDM4EUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720058-A2 BIFUNCTIONAL DEGRADERS AND USES THEREOF Casma Therapeutics, Inc. (US) 2026-04-08 — — EP disclosed
WO-2024249291-A2 BIFUNCTIONAL DEGRADERS AND USES THEREOF CASMA THERAPEUTICS, INC. (US) 2024-12-05 — — WO disclosed
US-20240246992-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS SERVIER LAB (FR) 2024-07-25 — — US disclosed
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 — — US disclosed
EP-4308570-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS Les Laboratoires Servier (FR) 2024-01-24 — — EP disclosed
CN-117425661-A Macrocyclic LRRK2 kinase inhibitors 法国施维雅药厂 2024-01-19 — — CN disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 — — US disclosed
WO-2022194976-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS LES LABORATOIRES SERVIER (FR) 2022-09-22 — — WO disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 — — US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 — — US disclosed
US-4642373-A Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents PFIZER INC. (US) 1987-02-10 — — US disclosed
EP-0090526-B1 SUBSTITUTED DODECAHYDROTRIPHENYLENES, DECAHYDRO-1H-CYCLOPENTA(1)PHENANTHRENES, DECAHYDRO-1H-PYRIDO(1,2-F)PHENANTHRIDINES AND DECAHYDROPYRROLO(1,2-F)PHENANTHRIDINES AS CNS AGENTS PFIZER INC. (US) 1986-11-26 — — EP disclosed
US-4576964-A ANALGESICS, ANTIEMETICS PFIZER INC. (US) 1986-03-18 — — US disclosed
EP-0079134-B1 STEREOSPECIFIC SYNTHESIS OF 5-PHENYL-2S-PENTANOL PFIZER INC. (US) 1985-02-06 — — EP disclosed
US-4476131-A ANTIEMETICS, ANALGESICS PFIZER INC. (US) 1984-10-09 — — US disclosed
US-4473704-A ANALGESICS, ANTIEMETICS PFIZER INC. (US) 1984-09-25 — — US disclosed
US-4412958-A Stereospecific synthesis of 5-phenyl-2S-pentanol PFIZER INC. (US) 1983-11-01 — — US disclosed
EP-0090516-A1 Substituted hexahydropyrrolo(1,2-a)-quinoline, hexahydro-1H-pyrido(1,2-a)-quinoline, hexahydrobenzo(3)indene and octahydrophenanthrene CNS agents PFIZER INC. (US) 1983-10-05 — — EP disclosed
EP-0090526-A1 Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta(1)phenanthrenes, decahydro-1H-pyrido(1,2-f)phenanthridines and decahydropyrrolo(1,2-f)phenanthridines as CNS agents PFIZER INC. (US) 1983-10-05 — — EP disclosed
EP-0079134-A1 Stereospecific synthesis of 5-phenyl-2S-pentanol PFIZER INC. (US) 1983-05-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER ALDH1A1 140/4885TSHR 2964/4885LMNA 565/4885
US-20240246992-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS LRRK2, PARK7, PINK1 ALDH1A1 4025/4885TSHR 3780/4885LMNA 2450/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER ALDH1A1 140/4885TSHR 2964/4885LMNA 565/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER ALDH1A1 133/4885TSHR 2971/4885LMNA 566/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER ALDH1A1 140/4885TSHR 2964/4885LMNA 565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.