SCHEMBL2083345

SCHEMBL2083345

Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(OCCN)cc3)nc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 15/20 1.00
SRC P12931 11/20 0.81
PDGFRB P09619 8/20 0.81
PDGFRA P16234 8/20 0.81
ABL1 P00519 6/20 0.78
MAPK14 Q16539 6/20 0.78
WEE1 P30291 4/20 0.78
EGFR P00533 4/20 0.78
FGFR2 P21802 2/20 0.78
FGFR4 P22455 2/20 0.78
FGFR3 P22607 2/20 0.78
CHEK1 O14757 1/20 0.78
RIPK2 O43353 1/20 0.78
JAK2 O60674 1/20 0.78
PRKD3 O94806 1/20 0.78
MAP4K4 O95819 1/20 0.78
PAK4 O96013 1/20 0.78
NTRK1 P04629 1/20 0.78
LCK P06239 1/20 0.78
FYN P06241 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10102543 0.92 FGFR1 (0.86) FGFR1SRCPDGFRBPDGFRAABL1
SCHEMBL5911585 0.91 FGFR1 (0.83) FGFR1SRCPDGFRBPDGFRAABL1
SCHEMBL1335649 0.90 FGFR1 (1.00) FGFR1SRCPDGFRBPDGFRAABL1
Pd-0166285 SCHEMBL30250248 0.88 FGFR1 (1.00) FGFR1SRCPDGFRBPDGFRAABL1
SCHEMBL29750113 0.88 FGFR1 (0.78) FGFR1SRCPDGFRBPDGFRAABL1
Pd-0166285 SCHEMBL133914 0.88 FGFR1 (1.00) FGFR1SRCPDGFRBPDGFRAABL1
SCHEMBL4747103 0.88 SRC (0.81) FGFR1SRCPDGFRBPDGFRAABL1
SCHEMBL5764000 0.88 FGFR1 (1.00) FGFR1SRCPDGFRBPDGFRAABL1
Pd-0166285 SCHEMBL15106017 0.87 FGFR1 (0.98) FGFR1SRCPDGFRBPDGFRAABL1
Pd-0166285 SCHEMBL30276696 0.87 FGFR1 (0.98) FGFR1SRCPDGFRBPDGFRAABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250116671-A1 Kinase Activity In Tumors INSTITUTE FOR CANCER RES D/B/A THE RES INSTITUTE OF FOX CHASE CANCER CENTER (US) 2025-04-10 US claimed
US-20250099508-A1 SYSTEMS, CELL LINES AND METHODS OF PRODUCING AND USING THE SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-03-27 US claimed
EP-4460314-A2 SYSTEMS, CELL LINES AND METHODS OF PRODUCING AND USING THE SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-11-13 EP claimed
WO-2023130150-A2 SYSTEMS, CELL LINES AND METHODS OF PRODUCING AND USING THE SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-07-06 WO claimed
US-20080220497-A1 Modulation of protein functionalities DECIPHERA PHARMACEUTICALS LLC 2008-09-11 US claimed
EP-1907411-A2 MODULATION OF PROTEIN FUNCTIONALITIES Deciphera Pharmaceuticals, LLC. (US) 2008-04-09 EP claimed
EP-1835934-A2 ENZYME MODULATORS AND TREATMENTS Deciphera Pharmaceuticals, LLC (US) 2007-09-26 EP claimed
US-20070078121-A1 Enzyme modulators and treatments DECIPHERA PHARMACEUTICALS, LLC 2007-04-05 US claimed
WO-2007008917-A2 MODULATION OF PROTEIN FUNCTIONALITIES DECIPHERA PHARMACEUTICALS, LLC (US) 2007-01-18 WO claimed
WO-2006071940-A2 ENZYME MODULATORS AND TREATMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2006-07-06 WO claimed
US-20060105445-A1 Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins GPC BIOTECH AG (DE) 2006-05-18 US claimed
EP-1527345-A2 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBILIZED PROTEIN INHIBITORS Axxima Pharmaceuticals AG (DE) 2005-05-04 EP claimed
WO-2004013633-A2 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBOLIZED PROTEIN INHIBITORS AXXIMA PHARMACEUTICALS AG (DE) 2004-02-12 WO claimed
EP-3954436-B1 METHOD FOR PRODUCING BIOTISSUE-LIKE STRUCTURE ORIZURU THERAPEUTICS INC (JP) 2026-01-07 EP disclosed
EP-4642465-A1 A CANCER ASSOCIATED FIBROBLAST (CAF) INHIBITOR FOR USE WITH AN ALTERNATING ELECTRIC FIELD IN A METHOD OF TREATING DISEASES SUCH AS CANCER Novocure GmbH (CH) 2025-11-05 EP disclosed
US-20250319190-A1 APOE LIPOPROTEIN SYSTEMS KISBEE THERAPEUTICS INC (US) 2025-10-16 US disclosed
EP-1527345-A2 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBILIZED PROTEIN INHIBITORS Axxima Pharmaceuticals AG (DE) 2005-05-04 EP disclosed
WO-2004013633-A3 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBOLIZED PROTEIN INHIBITORS AXXIMA PHARMACEUTICALS AG (DE) 2004-10-28 WO disclosed
WO-2004013633-A2 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBOLIZED PROTEIN INHIBITORS AXXIMA PHARMACEUTICALS AG (DE) 2004-02-12 WO disclosed
WO-2004013633-A2 METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBOLIZED PROTEIN INHIBITORS AXXIMA PHARMACEUTICALS AG (DE) 2004-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250319190-A1 APOE LIPOPROTEIN SYSTEMS APOB, APOL1, LDLR FGFR1 3599/4885SRC 1334/4885PDGFRB 1552/4885
US-20250099508-A1 SYSTEMS, CELL LINES AND METHODS OF PRODUCING AND USING THE SAME DCX, SLC10A2, CHAT FGFR1 2707/4885SRC 4575/4885PDGFRB 1721/4885
US-20060105445-A1 Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins ATP5MK, ATP5ME, ATP5MG FGFR1 4232/4885SRC 3851/4885PDGFRB 1479/4885
US-20080220497-A1 Modulation of protein functionalities C1QBP, SERPINA6, CD2BP2 FGFR1 4698/4885SRC 2604/4885PDGFRB 3462/4885
US-20070078121-A1 Enzyme modulators and treatments ABL1, ABL2, LCK FGFR1 118/4885SRC 9/4885PDGFRB 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.