SCHEMBL20847740

SCHEMBL20847740

N#Cc1ccc(CN(Sc2c(F)c(F)c(F)c(F)c2F)C2CC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 3/20 0.47
SLC6A2 P23975 3/20 0.40
SLC6A4 P31645 3/20 0.40
DPP4 P27487 1/20 0.39
DPP9 Q86TI2 1/20 0.39
DPP7 Q9UHL4 1/20 0.39
MAOA P21397 2/20 0.36
MAOB P27338 2/20 0.36
SLC6A3 Q01959 1/20 0.35
KDM1A O60341 3/20 0.34
CYP2A6 P11509 1/20 0.34
LOXL2 Q9Y4K0 1/20 0.34
CYP19A1 P11511 2/20 0.33
CHRM2 P08172 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
NSD3 Q9BZ95 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20847604 0.81 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3
SCHEMBL20847664 0.81 ESR1 (0.38) NSD2CYP19A1
SCHEMBL20847477 0.80 SLC6A2 (0.39) SLC6A2SLC6A4
SCHEMBL20847602 0.80 AGER (0.38) NSD2SLC6A2SLC6A4SLC6A3
SCHEMBL20847642 0.79 SLC6A4 (0.35) SLC6A2SLC6A4MAOASLC6A3
SCHEMBL20847669 0.78 AGER (0.40) NSD2SLC6A2SLC6A4SLC6A3
SCHEMBL20847650 0.78 ALDH1A1 (0.35) CYP19A1
SCHEMBL20847556 0.78 CA12 (0.33) MAOAMAOB
SCHEMBL20847622 0.78 L3MBTL1 (0.40) CHRM2CHRM1CHRM3
SCHEMBL20847575 0.77 AGER (0.42) SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019056120-A1 PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF DALRIADA THERAPEUTICS INC. (CA) 2019-03-28 WO disclosed