Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 3/20 | 0.41 |
| ▸ | ITK | Q08881 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19119582 | 0.83 | IDO1 (0.44) | IDO1TDO2MGLLPARP1KMT2A | |
| SCHEMBL14701440 | 0.74 | RBP4 (0.52) | MGLLKMT2AMEN1GAA | |
| SCHEMBL14003455 | 0.73 | HPGD (0.64) | MGLLKMT2AMEN1GAAHTT | |
| SCHEMBL13503785 | 0.72 | MGLL (0.62) | MGLLKMT2AMEN1ALDH1A1 | |
| SCHEMBL13504097 | 0.72 | SMN1; SMN2 (0.62) | MGLLSMN1; SMN2GAAHTTALDH1A1 | |
| SCHEMBL13503927 | 0.72 | LMNA (0.65) | MGLLKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2603247 | 0.71 | ACHE (0.68) | MGLLKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL13503779 | 0.70 | L3MBTL1 (0.64) | MGLLKMT2AMEN1GAAHTT | |
| SCHEMBL13503777 | 0.69 | MGLL (0.50) | MGLLKMT2ASMN1; SMN2MEN1TP53 | |
| SCHEMBL20805385 | 0.69 | HRH3 (0.52) | KMT2ASMN1; SMN2MEN1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190100515-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100515-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | IDO1 1991/4885TDO2 2535/4885MGLL 4366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.