Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | CA12 | O43570 | 6/20 | 0.64 |
| ▸ | CA9 | Q16790 | 6/20 | 0.64 |
| ▸ | CA1 | P00915 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | GLA | P06280 | 6/20 | 0.57 |
| ▸ | CASP1 | P29466 | 3/20 | 0.57 |
| ▸ | CASP7 | P55210 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929354 | 0.84 | CA12 (0.65) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL4927986 | 0.84 | ALDH1A1 (0.57) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL3361958 | 0.83 | ALDH1A1 (0.68) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL29673209 | 0.83 | CA12 (0.72) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL1034943 | 0.83 | CA12 (0.72) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL16266302 | 0.82 | ALDH1A1 (0.66) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL16316724 | 0.82 | ALDH1A1 (0.66) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL24865358 | 0.81 | ALDH1A1 (0.72) | ALDH1A1CA12CA9CA1LMNA | |
| SCHEMBL11227792 | 0.81 | CA12 (0.72) | ALDH1A1CA12CA9CA1KDM4E | |
| SCHEMBL26375305 | 0.81 | CA9 (0.72) | ALDH1A1CA12CA9CA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008495-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIV PARIS (FR) | 2023-01-12 | — | — | US | disclosed |
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | Universite De Paris (FR) | 2022-08-09 | — | — | US | disclosed |
| US-10961219-B2 | Derivatives and their use as selective inhibitors of caspase-2 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2021-03-30 | — | — | US | disclosed |
| US-20200317647-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIVERSITÉ PARIS CITÉ (FR) | 2020-10-08 | — | — | US | disclosed |
| US-20190100508-A1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIVERSITÉ PARIS CITÉ (FR) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008495-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | ALDH1A1 2295/4885CA12 1869/4885CA9 2582/4885 |
| US-20190100508-A1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | ALDH1A1 2103/4885CA12 1988/4885CA9 2911/4885 |
| US-10961219-B2 | Derivatives and their use as selective inhibitors of caspase-2 | CASP2, CASP1, CASP3 | ALDH1A1 2030/4885CA12 1553/4885CA9 2019/4885 |
| US-20200317647-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | ALDH1A1 2295/4885CA12 1869/4885CA9 2582/4885 |
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | CASP2, CASP1, CASP3 | ALDH1A1 2054/4885CA12 1486/4885CA9 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.