Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.37 |
| ▸ | NOS3 | P29474 | 6/20 | 0.37 |
| ▸ | NOS1 | P29475 | 8/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088900 | 0.82 | NOS2 (0.38) | NOS2NOS3NOS1 | |
| SCHEMBL2090059 | 0.79 | NOS3 (0.39) | NOS2NOS3NOS1 | |
| SCHEMBL2087138 | 0.74 | NOS3 (0.32) | NOS2NOS3NOS1 | |
| SCHEMBL5673354 | 0.74 | NOS2 (0.67) | NOS2NOS3NOS1 | |
| SCHEMBL2089986 | 0.71 | NOS2 (0.54) | NOS2NOS3NOS1 | |
| SCHEMBL2087998 | 0.69 | HTR6 (0.33) | NOS2NOS3NOS1 | |
| SCHEMBL21590377 | 0.69 | NOS2 (0.36) | NOS2NOS3NOS1 | |
| SCHEMBL793240 | 0.69 | NOS2 (0.41) | NOS2NOS3NOS1 | |
| SCHEMBL13741276 | 0.69 | CDK2 (0.37) | NOS2NOS3NOS1 | |
| SCHEMBL7562734 | 0.69 | MAPT (0.34) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163778-B2 | Pyridines as FBPase inhibitors for treatment of diabetes | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2227452-A2 | PYRIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068468-A2 | PYRIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |
| US-20090143439-A1 | NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES | HOFFMANN-LA ROCHE, INC. | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143439-A1 | NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES | FBP1, PDXK, G6PC1 | NOS2 3653/4885NOS3 3443/4885NOS1 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.