Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22567582 | 1.00 | GAA (0.38) | GAAG6PDL3MBTL1ALOX5DDB1 | |
| SCHEMBL22567323 | 0.86 | ADAMTS5 (0.34) | DDB1CRBNADAMTS5ALDH1A1 | |
| SCHEMBL22555807 | 0.86 | ADAMTS5 (0.34) | DDB1CRBNADAMTS5ALDH1A1 | |
| SCHEMBL22555747 | 0.84 | GAA (0.40) | GAAL3MBTL1DDB1CRBNALDH1A1 | |
| SCHEMBL20898255 | 0.82 | PDE3B (0.38) | GAAL3MBTL1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL22555783 | 0.81 | LMNA (0.40) | GAAL3MBTL1ALDH1A1HPGD | |
| SCHEMBL22567300 | 0.81 | LMNA (0.40) | GAAL3MBTL1ALDH1A1HPGD | |
| SCHEMBL22555768 | 0.81 | LMNA (0.40) | GAAL3MBTL1ALDH1A1HPGD | |
| SCHEMBL29616666 | 0.81 | MEN1 (0.44) | GAAL3MBTL1DDB1CRBNHSD17B10 | |
| SCHEMBL22567593 | 0.78 | ALDH1A1 (0.36) | GAAG6PDL3MBTL1ALOX5DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12060360-B2 | Lysyl oxidase inhibitors | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2024-08-13 | — | — | US | disclosed |
| US-20220289757-A1 | LYSYL OXIDASE INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2022-09-15 | — | — | US | disclosed |
| US-11325915-B2 | Lysyl oxidase inhibitors | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2022-05-10 | — | — | US | disclosed |
| US-11325915-B2 | Lysyl oxidase inhibitors | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2022-05-10 | — | — | US | disclosed |
| US-20200331922-A1 | LYSYL OXIDASE INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-10-22 | — | — | US | disclosed |
| US-20200331922-A1 | LYSYL OXIDASE INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-10-22 | — | — | US | disclosed |
| EP-3694857-A1 | LYSYL OXIDASE INHIBITORS | The Institute of Cancer Research: Royal Cancer Hospital (GB) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019073251-A1 | LYSYL OXIDASE INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2019-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331922-A1 | LYSYL OXIDASE INHIBITORS | LOXL1, LOXL2, LOXL3 | GAA 437/4885G6PD 2693/4885L3MBTL1 312/4885 |
| US-12060360-B2 | Lysyl oxidase inhibitors | LOXL1, LOXL2, LOXL3 | GAA 437/4885G6PD 2693/4885L3MBTL1 312/4885 |
| US-20220289757-A1 | LYSYL OXIDASE INHIBITORS | LOXL1, LOXL2, LOXL3 | GAA 437/4885G6PD 2693/4885L3MBTL1 312/4885 |
| US-11325915-B2 | Lysyl oxidase inhibitors | LOXL1, LOXL2, LOXL3 | GAA 437/4885G6PD 2693/4885L3MBTL1 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.