Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 2/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20908739 | 0.89 | MMP1 (0.48) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20908743 | 0.86 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL3697518 | 0.80 | NAMPT (0.63) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22766532 | 0.77 | OPRK1 (0.48) | ALDH1A1MEN1KMT2AKDM4ESIGMAR1 | |
| SCHEMBL7598909 | 0.77 | CRHBP (0.58) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27448293 | 0.77 | CRHBP (0.57) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22766731 | 0.76 | OPRK1 (0.50) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22766813 | 0.75 | OPRK1 (0.52) | ALDH1A1MEN1KMT2AKDM4ESIGMAR1 | |
| SCHEMBL5506263 | 0.75 | REN (0.51) | ALDH1A1LMNASMN1; SMN2RENMEN1 | |
| SCHEMBL21800147 | 0.74 | CRHBP (0.55) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694836-B1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | ZAI LAB SHANGHAI CO LTD (CN) | 2022-06-15 | — | — | EP | disclosed |
| US-10927077-B2 | Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof | ZAI LAB (SHANGHAI) CO., LTD. (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20200385350-A1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | ZAI LAB (SHANGHAI) CO., LTD. (CN) | 2020-12-10 | — | — | US | disclosed |
| WO-2019072237-A1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | ZAI LAB (SHANGHAI) CO., LTD. (CN) | 2019-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927077-B2 | Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof | PARP1, PARP2, TOP2B | CRHBP 3302/4885CRHR2 3537/4885ALDH1A1 893/4885 |
| US-20200385350-A1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | PARP1, PARP2, TOP2B | CRHBP 3302/4885CRHR2 3537/4885ALDH1A1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.