Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 5/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.35 |
| ▸ | ABAT | P80404 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024626 | 0.88 | ERN1 (0.46) | HSD17B10ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL16095449 | 0.84 | ERN1 (0.41) | HSD17B10ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL1459005 | 0.84 | HSD17B10 (0.41) | HSD17B10ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL4890459 | 0.78 | ESR1 (0.50) | ALDH1A1TDP1MEN1KMT2AERN1 | |
| SCHEMBL94930 | 0.78 | ALDH1A1 (0.55) | HSD17B10ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL6111862 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TDP1MEN1KMT2AERN1 | |
| SCHEMBL17056841 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL2429712 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TDP1MEN1KMT2AERN1 | |
| SCHEMBL320379 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TDP1MEN1KMT2AERN1 | |
| SCHEMBL3069036 | 0.73 | TTR (0.58) | HSD17B10ALDH1A1TDP1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-B1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | HOFFMANN LA ROCHE (CH) | 2007-05-30 | — | — | EP | claimed |
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | claimed |
| US-6790852-B2 | HETEROCYCLIC NITROGEN COMPOUNDS SUCH AS 2-(2,6-DICHLOROPHENYL) -4-(3-BROMOPHENYL)-5-(2-(3- HYDROXYPROPYLAMINO)PYRIMIDIN-4-YL) -N-H-IMIDAZOLE, USED AS TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC OR ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2004-09-14 | — | — | US | claimed |
| US-20030199691-A1 | 2-(2,6-dichlorophenyl)-diarylimidazoles | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | US | claimed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | claimed |
| US-12528761-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12466781-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2025-11-11 | — | — | US | disclosed |
| US-20240425437-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2024-12-26 | — | — | US | disclosed |
| CN-115003778-B | Boron-containing cyclic light-emitting compound and color conversion film comprising same | 日东电工株式会社 | 2024-09-17 | — | — | CN | disclosed |
| CN-118251979-A | Wavelength conversion film and display device including the same | 日东电工株式会社 | 2024-06-25 | — | — | CN | disclosed |
| US-12006294-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2024-06-11 | — | — | US | disclosed |
| WO-2024081802-A1 | WAVELENGTH CONVERSION FILM AND DISPLAY DEVICE INCLUDING THE SAME | NITTO DENKO CORPORATION (US) | 2024-04-18 | — | — | WO | disclosed |
| US-20030199691-A1 | 2-(2,6-dichlorophenyl)-diarylimidazoles | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | US | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |
| US-4853383-A | β-blocking substituted imidazoles | MERCK & CO., INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4642311-A | β-adrenergic blocking imidazolylphenoxy propanolamines | MERCK & CO., INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4567276-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4440774-A | ANTIHYPERTENSIVE AGENTS AND B-ANDRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4199580-A | HYPOTENSIVE AGENTS AND ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4134983-A | HYPOTENSIVE, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1979-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12466781-B2 | Thyromimetics | TPO, TSHR, CHRM1 | HSD17B10 1760/4885ALDH1A1 1070/4885CYP3A4 1047/4885 |
| US-12006294-B2 | Therapeutic compounds | OPRL1, INA, OGFR | HSD17B10 4520/4885ALDH1A1 1048/4885CYP3A4 1976/4885 |
| US-20030199691-A1 | 2-(2,6-dichlorophenyl)-diarylimidazoles | CYP2D6, CYP2F1, CYP1A2 | HSD17B10 291/4885ALDH1A1 115/4885CYP3A4 49/4885 |
| US-20240425437-A1 | DERIVATIVES OF SOBETIROME | SNCA, SLC6A3, SLC6A1 | HSD17B10 988/4885ALDH1A1 559/4885CYP3A4 788/4885 |
| US-12528761-B2 | Thyromimetics | TSHR, THRB, TTR | HSD17B10 870/4885ALDH1A1 1038/4885CYP3A4 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.