Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 7/20 | 0.39 |
| ▸ | MAOB | P27338 | 7/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20775919 | 0.96 | HTR1A (0.52) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL20945218 | 0.95 | HTR1A (0.51) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL24392332 | 0.77 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BRAD52 | |
| SCHEMBL20962992 | 0.74 | HTR1A (0.85) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL6215368 | 0.73 | HTR1A (0.44) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL15924403 | 0.73 | LOXL2 (0.50) | HTR1AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL20962967 | 0.73 | HTR1A (0.87) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL20779743 | 0.73 | HTR1A (0.87) | HTR1AADRA1DADRA1AADRA1BHASPIN | |
| SCHEMBL7370612 | 0.70 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL5754351 | 0.70 | SIGMAR1 (0.47) | HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774046-B2 | Inhibitors for the treatment of cancer and related methods | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190127329-A1 | INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774046-B2 | Inhibitors for the treatment of cancer and related methods | PFKFB4, PDK4, PFKFB1 | HTR1A 3405/4885ADRA1D 3703/4885ADRA1A 3950/4885 |
| US-20190127329-A1 | INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS | PFKFB4, PDK4, PFKFB1 | HTR1A 3405/4885ADRA1D 3703/4885ADRA1A 3950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.