Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | EBP | Q15125 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760090 | 0.90 | ABCB1 (0.47) | SIGMAR1EBPTMEM97ADRA1DADRA1A | |
| SCHEMBL5754347 | 0.80 | CCR8 (0.51) | SIGMAR1HTR1A | |
| SCHEMBL6626086 | 0.77 | HTR1A (0.47) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL6628061 | 0.70 | HTR1A (0.54) | SIGMAR1ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL5757154 | 0.70 | L3MBTL1 (0.54) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL5777034 | 0.70 | HTR1A (0.49) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL5757405 | 0.70 | SLC2A1 (0.59) | SIGMAR1HTR1A | |
| SCHEMBL20945281 | 0.70 | HTR1A (0.53) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL3692137 | 0.69 | MEN1 (0.49) | SIGMAR1 | |
| SCHEMBL20775919 | 0.69 | HTR1A (0.52) | ADRA1DADRA1AADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343765-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERAZINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2006-11-22 | — | — | EP | claimed |