Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332685 | 0.86 | YAP1 (0.71) | KDM4EMAPTPTPN2PTPN1FAAH | |
| SCHEMBL19520251 | 0.86 | PTPN2 (0.71) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL315809 | 0.85 | MGLL (0.67) | TRPV1PTPN2PTPN1FAAHYAP1 | |
| SCHEMBL19302972 | 0.84 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL7865123 | 0.84 | NAMPT (0.72) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL25668532 | 0.82 | KDM4E (0.63) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| Hydrochloric Acid SCHEMBL435505 | 0.82 | NAMPT (0.70) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL23245968 | 0.82 | UBE2M (0.56) | ALDH1A1KDM4EMAPTPOLBPTPN2 | |
| SCHEMBL23246064 | 0.81 | RHOC (0.60) | ALDH1A1MAPTTRPV1PTPN2PTPN1 | |
| SCHEMBL1339196 | 0.80 | PTPN1 (0.71) | ALDH1A1KDM4EMAPTCYP2C19PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448850-B1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-10428024-B2 | Piperidinyl derivatives | MERCK PATENT GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428024-B2 | Piperidinyl derivatives | PDK1, PDK2, PDK3 | ALDH1A1 82/4885KDM4E 1034/4885MAPT 4278/4885 |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | PDK1, PDK2, PDK3 | ALDH1A1 82/4885KDM4E 1034/4885MAPT 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.