Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | USP9X | Q93008 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20970271 | 1.00 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2USP9XPKM | |
| SCHEMBL20970260 | 1.00 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2USP9XPKM | |
| SCHEMBL21151407 | 0.83 | LMNA (0.43) | ALDH1A1LMNASMN1; SMN2USP9XNAMPT | |
| SCHEMBL25064335 | 0.82 | LMNA (0.42) | ALDH1A1LMNASMN1; SMN2USP9XPKM | |
| SCHEMBL21005033 | 0.81 | LMNA (0.46) | ALDH1A1LMNASMN1; SMN2USP9XTSHR | |
| SCHEMBL21004705 | 0.81 | NAMPT (0.38) | NAMPTEPHX2 | |
| SCHEMBL21004651 | 0.80 | NAMPT (0.39) | LMNANAMPTEPHX2 | |
| SCHEMBL21005032 | 0.78 | LMNA (0.44) | ALDH1A1LMNASMN1; SMN2USP9XTSHR | |
| SCHEMBL28958551 | 0.76 | LMNA (0.47) | ALDH1A1LMNASMN1; SMN2USP9XPKM | |
| SCHEMBL30255297 | 0.75 | USP9X (0.41) | ALDH1A1LMNASMN1; SMN2USP9XTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3483164-B1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | FORMA THERAPEUTICS INC (US) | 2020-03-04 | — | — | EP | claimed |
| US-20240083901-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | NOVO NORDISK HEALTH CARE AG (CH) | 2024-03-14 | — | — | US | disclosed |
| US-11649242-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | FORMA THERAPEUTICS, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20210246143-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | NOVO NORDISK HEALTH CARE AG, (CH) | 2021-08-12 | — | — | US | disclosed |
| US-11014927-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | FORMA THERAPEUTICS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| EP-3680241-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | Forma Therapeutics, Inc. (US) | 2020-07-15 | — | — | EP | disclosed |
| US-20200069643-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | NOVO NORDISK HEALTH CARE AG, (CH) | 2020-03-05 | — | — | US | disclosed |
| EP-3483164-B1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | FORMA THERAPEUTICS INC (US) | 2020-03-04 | — | — | EP | disclosed |
| EP-3483164-B1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | FORMA THERAPEUTICS INC (US) | 2020-03-04 | — | — | EP | disclosed |
| EP-3448859-B1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | FORMA THERAPEUTICS INC (US) | 2019-07-10 | — | — | EP | disclosed |
| EP-3483164-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | Forma Therapeutics, Inc. (US) | 2019-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069643-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | PDK1, PKM, PKLR | ALDH1A1 2884/4885LMNA 1753/4885SMN1; SMN2 1396/4885 |
| US-11014927-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | PDK1, PKM, PKLR | ALDH1A1 2884/4885LMNA 1753/4885SMN1; SMN2 1396/4885 |
| US-20240083901-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | PDK1, PKM, PKLR | ALDH1A1 3741/4885LMNA 2219/4885SMN1; SMN2 1093/4885 |
| US-20210246143-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | PDK1, PKM, PKLR | ALDH1A1 3741/4885LMNA 2219/4885SMN1; SMN2 1093/4885 |
| US-11649242-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | PDK1, PKM, PKLR | ALDH1A1 3741/4885LMNA 2219/4885SMN1; SMN2 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.