Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL19183294 | 0.84 | LMNA (0.62) | TDP1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL4342621 | 0.82 | TDP1 (0.63) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL414549 | 0.82 | TDP1 (0.63) | TDP1LMNAALOX15BLMPMP22 | |
| Tromethamine SCHEMBL5710709 | 0.81 | LMNA (0.67) | TDP1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL4332087 | 0.80 | TDP1 (0.60) | TDP1LMNAALOX15BLMPMP22 | |
| Tromethamine SCHEMBL4581519 | 0.78 | LMNA (0.62) | TDP1LMNAMEN1KMT2AALOX15 | |
| Tert-Butylamine SCHEMBL7649267 | 0.78 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 | |
| Tromethamine SCHEMBL194002 | 0.78 | LMNA (0.62) | TDP1LMNAMEN1KMT2AALOX15 | |
| Tromethamine SCHEMBL7347818 | 0.78 | LMNA (0.62) | TDP1LMNAMEN1KMT2AALOX15 | |
| Ethylene Glycol SCHEMBL860665 | 0.78 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9097839-B2 | Method for making silicone hydrogel contact lenses | NOVARTIS AG (CH) | 2015-08-04 | — | — | US | disclosed |
| US-20120172478-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | ALCON INC. (CH) | 2012-07-05 | — | — | US | disclosed |
| US-8163206-B2 | Method for making silicone hydrogel contact lenses | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| EP-2374031-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | Novartis AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| US-20100258961-A1 | Method for making silicone hydrogel contact lenses | ALCON INC. (CH) | 2010-10-14 | — | — | US | disclosed |
| WO-2010071691-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | NOVARTIS AG (CH) | 2010-06-24 | — | — | WO | disclosed |