Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706747 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL21043473 | 0.79 | ALDH1A1 (0.56) | ENPP2ALDH1A1SMN1; SMN2HTTTHRB | |
| SCHEMBL17968561 | 0.76 | ENPP2 (1.00) | ENPP2ALDH1A1THRBRXFP1KMT2A | |
| SCHEMBL17968559 | 0.76 | ENPP2 (1.00) | ENPP2ALDH1A1THRBRXFP1KMT2A | |
| SCHEMBL16596364 | 0.75 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2HTTTHRBKMT2A | |
| SCHEMBL16591993 | 0.73 | ENPP2 (0.80) | ENPP2ALDH1A1SMN1; SMN2THRBRXFP1 | |
| SCHEMBL8690446 | 0.72 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL25169082 | 0.71 | ALDH1A1 (0.45) | ENPP2ALDH1A1SMN1; SMN2RXFP1KMT2A | |
| SCHEMBL16591995 | 0.70 | MAPT (0.45) | ENPP2ALDH1A1HTTTHRBKMT2A | |
| SCHEMBL22001748 | 0.68 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTTHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951026-B2 | Heterocyclic vinyl autotaxin inhibitor compounds | PHARMAKEA, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951026-B2 | Heterocyclic vinyl autotaxin inhibitor compounds | PHARMAKEA, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951026-B2 | Heterocyclic vinyl autotaxin inhibitor compounds | PHARMAKEA, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160229809-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | DF 2024 IP ACQUISITION, LLC | 2016-08-11 | — | — | US | disclosed |
| US-20160229809-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | DF 2024 IP ACQUISITION, LLC | 2016-08-11 | — | — | US | disclosed |
| US-20160229809-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | DF 2024 IP ACQUISITION, LLC | 2016-08-11 | — | — | US | disclosed |
| EP-3046909-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | Pharmakea Inc. (US) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015042052-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015042052-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229809-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | ENPP2, SERPINB1, UACA | ENPP2 1/4885ALDH1A1 4308/4885SMN1; SMN2 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.