SCHEMBL2104422

SCHEMBL2104422

O=C(Cl)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.69
MEN1 O00255 3/20 0.69
KMT2A Q03164 3/20 0.69
MAPT P10636 2/20 0.69
NPC1 O15118 2/20 0.69
LMNA P02545 2/20 0.69
PTGS1 P23219 3/20 0.68
KCNK3 O14649 1/20 0.63
CES1 P23141 1/20 0.60
PPARG P37231 2/20 0.60
PPARD Q03181 2/20 0.60
NR1H4 Q96RI1 2/20 0.60
PPARA Q07869 1/20 0.60
RHOC P08134 1/20 0.60
RHOA P61586 1/20 0.60
RXFP1 Q9HBX9 1/20 0.59
P2RX1 P51575 1/20 0.57
EPHX2 P34913 1/20 0.57
HTT P42858 1/20 0.57
POLB P06746 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2012089 0.90 MAPT (0.76) RAB9AMEN1KMT2AMAPTLMNA
SCHEMBL7519747 0.88 MAPT (0.82) RAB9AMEN1KMT2AMAPTNPC1
SCHEMBL23070449 0.87 NR1H4 (0.72) RAB9AMEN1KMT2AMAPTNPC1
Hydrochloric Acid SCHEMBL2104426 0.85 NR1H4 (0.70) RAB9AMEN1KMT2AMAPTNPC1
SCHEMBL2009691 0.85 MEN1 (0.76) RAB9AMEN1KMT2AMAPTNPC1
SCHEMBL23447711 0.84 MAPT (0.82) RAB9AMEN1KMT2AMAPTNPC1
SCHEMBL1359652 0.84 KCNK3 (0.76) RAB9AMEN1KMT2AMAPTNPC1
SCHEMBL7607259 0.84 APOB (0.59) MAPTLMNAKCNK3PPARGPPARD
SCHEMBL2105693 0.83 RAB9A (0.69) RAB9AMEN1KMT2ANPC1LMNA
SCHEMBL2012930 0.83 KCNK3 (0.67) RAB9AMEN1KMT2AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2023-11-23 US disclosed
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2023-09-19 US disclosed
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2021-07-29 US disclosed
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2021-05-04 US disclosed
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2019-10-08 US disclosed
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2018-05-17 US disclosed
US-9920026-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2018-03-20 US disclosed
EP-1714958-B9 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2017-05-31 EP disclosed
EP-1714958-B1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2016-12-21 EP disclosed
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2016-01-07 US disclosed
CN-1926094-B Amide derivatives, process for their preparation and their use as pesticides MITSUI CHEMICALS INC 2011-05-25 CN disclosed
CN-101906053-A Amide derivatives MITSUI CHEMICALS INC 2010-12-08 CN disclosed
US-20090192167-A1 Insecticidal and fungicidal composition MITSUI CHEMICALS, INC. (JP) 2009-07-30 US disclosed
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS MITSUI CHEMICALS, INC (JP) 2009-06-25 US disclosed
CN-101367748-A Amide derivatives, process for production of the same, and method for application thereof as insecticide MITSUI CHEMICALS INC (JP) 2009-02-18 CN disclosed
EP-1938685-A1 INSECTICIDAL AND BACTERICIDAL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-07-02 EP disclosed
EP-1913815-A1 PEST CONTROL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-04-23 EP disclosed
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide MITSUI CHEMICALS, INC. (JP) 2007-11-29 US disclosed
CN-1926094-A Amide derivatives, process for their preparation and their use as pesticides MITSUI CHEMICALS INC (JP) 2007-03-07 CN disclosed
EP-1714958-A1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE Mitsui Chemicals, Inc. (JP) 2006-10-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide CYP1A1, CYP4B1, CYP2E1 RAB9A 2488/4885MEN1 3376/4885KMT2A 1782/4885
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 RAB9A 2488/4885MEN1 3376/4885KMT2A 1782/4885
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 RAB9A 2488/4885MEN1 3376/4885KMT2A 1782/4885
US-20090192167-A1 Insecticidal and fungicidal composition NOX3, PRDX1, CYP4X1 RAB9A 1575/4885MEN1 1780/4885KMT2A 2083/4885
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 RAB9A 377/4885MEN1 2759/4885KMT2A 565/4885
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 RAB9A 377/4885MEN1 2759/4885KMT2A 565/4885
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 RAB9A 377/4885MEN1 2759/4885KMT2A 565/4885
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS PRDX3, CYP1A1, GSTA1 RAB9A 2241/4885MEN1 485/4885KMT2A 1594/4885
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 RAB9A 377/4885MEN1 2759/4885KMT2A 565/4885
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 RAB9A 377/4885MEN1 2759/4885KMT2A 565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.