SCHEMBL21048265

SCHEMBL21048265

O=C1N=C(Nc2cccc(O)c2)S/C1=C\c1c[nH]c2ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.42
AURKA O14965 1/20 0.41
EGFR P00533 1/20 0.41
ERBB2 P04626 1/20 0.41
SRC P12931 1/20 0.41
ACVR1 Q04771 1/20 0.41
PTK6 Q13882 1/20 0.41
ALK Q9UM73 1/20 0.41
AURKC Q9UQB9 1/20 0.41
MAPK14 Q16539 1/20 0.41
PIK3CA P42336 1/20 0.40
MTOR P42345 1/20 0.40
SENP7 Q9BQF6 2/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
MAPT P10636 7/20 0.38
MEN1 O00255 6/20 0.38
KMT2A Q03164 6/20 0.38
KDM4E B2RXH2 5/20 0.38
ALDH1A1 P00352 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29801454 1.00 MIF (0.42) MIFAURKAEGFRERBB2SRC
SCHEMBL21048266 1.00 MIF (0.42) MIFAURKAEGFRERBB2SRC
SCHEMBL29801391 0.88 SENP8 (0.52) SENP7SENP8SENP6MAPTMEN1
SCHEMBL21074342 0.88 SENP8 (0.52) SENP7SENP8SENP6MAPTMEN1
SCHEMBL21074343 0.88 BACE1 (0.43) MIFALKPIK3CAMTORSENP7
SCHEMBL19859149 0.88 SENP7 (0.44) ALKSENP7SENP8SENP6MAPT
SCHEMBL29801683 0.88 SENP7 (0.44) ALKSENP7SENP8SENP6MAPT
SCHEMBL29801540 0.88 PRKCB (0.47) EGFRERBB2PTK6SENP7SENP8
SCHEMBL21074378 0.88 STING1 (0.43) EGFRALKMAPK14SENP7SENP8
SCHEMBL29801537 0.88 STING1 (0.43) EGFRALKMAPK14SENP7SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12343335-B2 Pharmaceutical composition for treating multiple sclerosis on basis of AMPK inhibitory function and zinc homeostasis control function ZINCURE CORP. (KR) 2025-07-01 US claimed
US-20230000839-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION ZINCURE CORP. (KR) 2023-01-05 US claimed
EP-4066832-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION Zincure Corp. (KR) 2022-10-05 EP claimed
WO-2021096270-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION 주식회사 진큐어 2021-05-20 WO claimed
US-12343335-B2 Pharmaceutical composition for treating multiple sclerosis on basis of AMPK inhibitory function and zinc homeostasis control function ZINCURE CORP. (KR) 2025-07-01 US disclosed
US-20230000839-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION ZINCURE CORP. (KR) 2023-01-05 US disclosed
US-20230000839-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION ZINCURE CORP. (KR) 2023-01-05 US disclosed
EP-4066832-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION Zincure Corp. (KR) 2022-10-05 EP disclosed
EP-3498277-B1 PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION ZINCURE CORP (KR) 2021-10-06 EP disclosed
WO-2021096270-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION 주식회사 진큐어 2021-05-20 WO disclosed
EP-3498277-A1 PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION Industry Academy Cooperation Foundation Of Sejong University (KR) 2019-06-19 EP disclosed
US-20190167647-A1 PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION ZINCURE CORP. (KR) 2019-06-06 US disclosed
US-20190167647-A1 PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION ZINCURE CORP. (KR) 2019-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230000839-A1 PHARMACEUTICAL COMPOSITION FOR TREATING MULTIPLE SCLEROSIS ON BASIS OF AMPK INHIBITORY FUNCTION AND ZINC HOMEOSTASIS CONTROL FUNCTION PRKAB1, PRKAB2, PRKAG1 MIF 1463/4885AURKA 4445/4885EGFR 3810/4885
US-20190167647-A1 PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION PRKAG1, PRKAB1, PRKAG2 MIF 4423/4885AURKA 1674/4885EGFR 3119/4885
US-12343335-B2 Pharmaceutical composition for treating multiple sclerosis on basis of AMPK inhibitory function and zinc homeostasis control function PRKAB1, PRKAB2, PRKAG1 MIF 1463/4885AURKA 4445/4885EGFR 3810/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.