Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048953 | 0.87 | LMNA (0.53) | PGRKEAP1NFE2L2LMNAKMT2A | |
| SCHEMBL21048781 | 0.87 | C5AR1 (0.50) | LMNAKMT2APTGER1MAPTGAA | |
| Hydrochloric Acid SCHEMBL21048836 | 0.80 | PGR (0.56) | PGRKEAP1NFE2L2LMNATAS2R14 | |
| SCHEMBL17258875 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2KMT2AMAPTGAA | |
| SCHEMBL17258893 | 0.76 | ALDH1A1 (0.53) | KMT2AGAAHPGDMEN1 | |
| SCHEMBL21048813 | 0.75 | TP53 (0.41) | KMT2APTGER1GAAHPGD | |
| SCHEMBL21048834 | 0.75 | TP53 (0.42) | KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL21048892 | 0.74 | PTGER1 (0.50) | KEAP1NFE2L2PTGER1MAPTHPGD | |
| SCHEMBL3462321 | 0.72 | PGR (0.70) | PGRLMNAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL17259042 | 0.71 | PGR (0.57) | PGRKEAP1NFE2L2TAS2R14HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |