Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383748 | 1.00 | HSD11B1 (0.39) | HSD11B1ALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL31419781 | 1.00 | HSD11B1 (0.39) | HSD11B1ALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1383097 | 0.84 | LMNA (0.51) | ALDH1A1HPGDMAPTRAB9AMEN1 | |
| SCHEMBL1605432 | 0.83 | AKT1 (0.36) | HSD11B1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL1605555 | 0.83 | ALDH1A1 (0.39) | ALDH1A1RAB9AKMT2ANPC1HTT | |
| SCHEMBL1383688 | 0.83 | CCR4 (0.40) | HPGDMAPTKMT2ANPC1LMNA | |
| SCHEMBL1605573 | 0.83 | DHODH (0.38) | ALDH1A1HPGDMAPTRAB9AKMT2A | |
| SCHEMBL1605797 | 0.82 | KMT2A (0.44) | ALDH1A1HPGDMAPTRAB9AMEN1 | |
| SCHEMBL5549464 | 0.81 | HPGD (0.46) | ALDH1A1HPGDMAPTRAB9AMEN1 | |
| SCHEMBL1606506 | 0.81 | MAPT (0.45) | ALDH1A1HPGDMAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137658-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | disclosed |
| US-20260137659-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | disclosed |
| US-20250319072-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-12329745-B2 | Methods and compositions for treating glucocorticoid excess | SPARROW PHARMACEUTICALS, INC. (US) | 2025-06-17 | — | — | US | disclosed |
| US-20240293375-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | FIRST-CITIZENS BANK & TRUST COMPANY | 2024-09-05 | — | — | US | disclosed |
| WO-2023225507-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| US-20230364060-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-11-16 | — | — | US | disclosed |
| US-20230364060-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-11-16 | — | — | US | disclosed |
| US-20230364060-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-11-16 | — | — | US | disclosed |
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240293375-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885ALDH1A1 622/4885HPGD 58/4885 |
| US-20250319072-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885ALDH1A1 622/4885HPGD 58/4885 |
| US-12329745-B2 | Methods and compositions for treating glucocorticoid excess | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885ALDH1A1 622/4885HPGD 58/4885 |
| US-20230364060-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885ALDH1A1 622/4885HPGD 58/4885 |
| US-20260137659-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | NR3C2, NR3C1, MC2R | HSD11B1 4/4885ALDH1A1 3178/4885HPGD 1183/4885 |
| US-20260137658-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | NR3C1, NR3C2, NR5A1 | HSD11B1 5/4885ALDH1A1 3350/4885HPGD 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.