Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PPID | Q08752 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31059203 | 0.85 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDL3MBTL1HTT | |
| SCHEMBL11320449 | 0.83 | TOP2A (0.56) | ALDH1A1KDM4EL3MBTL1PTPN1ELANE | |
| SCHEMBL11292099 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EL3MBTL1PTPN1ELANE | |
| SCHEMBL11328568 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4EL3MBTL1PTPN1ELANE | |
| SCHEMBL5786263 | 0.81 | GAA (0.54) | ALDH1A1KDM4EPPIDELANEHTT | |
| SCHEMBL31518574 | 0.80 | KDM4E (0.58) | ALDH1A1KDM4EHPGDL3MBTL1PPID | |
| SCHEMBL29926725 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDPPIDELANE | |
| SCHEMBL6909147 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDPPIDELANE | |
| SCHEMBL7415643 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4EPPIDELANEHTT | |
| Hydrochloric Acid SCHEMBL8122459 | 0.80 | GAA (0.53) | ALDH1A1KDM4EPPIDELANEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250049804-A1 | FERROCHELATASE INHIBITORS AND METHODS OF USE | UNIV INDIANA RES & TECH CORP (US) | 2025-02-13 | — | — | US | disclosed |
| US-12161642-B2 | Ferrochelatase inhibitors and methods of use | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2024-12-10 | — | — | US | disclosed |
| US-20210121465-A1 | FERROCHELATASE INHIBITORS AND METHODS OF USE | GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2021-04-29 | — | — | US | disclosed |
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | disclosed |
| US-8163793-B2 | Proline derivatives | HOFFMAN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250049804-A1 | FERROCHELATASE INHIBITORS AND METHODS OF USE | FECH, SLC40A1, TPI1 | ALDH1A1 701/4885KDM4E 1246/4885HPGD 564/4885 |
| US-20210121465-A1 | FERROCHELATASE INHIBITORS AND METHODS OF USE | FECH, SLC40A1, TPI1 | ALDH1A1 701/4885KDM4E 1246/4885HPGD 564/4885 |
| US-12161642-B2 | Ferrochelatase inhibitors and methods of use | FECH, SLC40A1, TPI1 | ALDH1A1 701/4885KDM4E 1246/4885HPGD 564/4885 |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | PRAP1, PRR12, SLC6A7 | ALDH1A1 727/4885KDM4E 2752/4885HPGD 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.